Evidence map›Paper›PMID 25330848›Full record

Trial reportBMC pediatrics2014

A randomized controlled trial on a multicomponent intervention for overweight school-aged children - Copenhagen, Denmark.

Nina Majlund Harder-Lauridsen, Nina Marie Birk, Mathias Ried-Larsen, Anders Juul, Lars Bo Andersen, Bente Klarlund Pedersen, Rikke Krogh-Madsen

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01660789 ("Fit For Kids" Copenhagen - an Interventions Study on Obesity and Physical Inactivity in Children.), which is not on this map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01660789 nacompletednot on this map

"Fit For Kids" Copenhagen - an Interventions Study on Obesity and Physical Inactivity in Children.

TypeinterventionalSponsorRigshospitalet, DenmarkRan2012 to 2012Enrolled37ConditionsObesityArmsPhysical activity, dietary counseling, coaching
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Interventions for preventing obesity in children.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Pooled it
  4. Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2017 · on this map
    Guideline
  5. Trial
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nina Majlund Harder-LauridsenDepartment of Infectious Diseases The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, the Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Nina.Majlund.Harder@regionh.dk.
Nina Marie Birk
Mathias Ried-Larsen
Anders Juul
Lars Bo Andersen
Bente Klarlund Pedersen
Rikke Krogh-Madsen
University of Copenhagen · DKRigshospitalet · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity amongst children is a growing problem worldwide. In contrast to adults, little is known on the effects of controlled weight loss on components of the metabolic syndrome in children. The primary aim of the study was to evaluate the effects of a 20-week exercise and diet guidance intervention on body mass index (BMI) in a group of overweight children. Our hypothesis was an observed reduction in BMI and secondarily in body fat content, insulin insensitivity, and other components of the metabolic syndrome in the intervention group.

methodsSchool children from Copenhagen were randomly allocated to an intervention group (n = 19) or a control group (n = 19). Anthropometric assessment, whole body dual-energy X-ray absorptiometry scan, two hours oral glucose tolerance test, steps measured by pedometer, and fitness tests were measured at baseline and at 20 weeks.

resultsThirty-seven children (30 girls) participated at baseline, aged 8.7 ± 0.9 years with a BMI of 21.8 ± 3.7 kg/m2 (mean ± SD), and 36 children completed the study. The intervention group decreased their BMI (the intervention effect is the difference in change between the groups adjusted for the respective baseline values (DELTA) = -2.0 kg/m2, 95% CI: -2.5; -1.5, P <0.001), total body mass (DELTA = -4.0 kg, 95% CI: -4.9; -3.0, P <0.001), and fat mass (DELTA = -3.3 kg, 95% CI: -4.2; -2.7, P <0.001) compared to the control group after the intervention. The intervention group displayed decreased waist, hip and waist-to-height ratio (WHtR) (all three variables; P <0.001), area under curve for plasma insulin (P <0.05), and increased mean and minimum steps/day (P <0.05 and P <0.01, respectively).

conclusionsThe multicomponent intervention had significant favorable effects on BMI, weight, WHtR, mean and minimum steps/day, and fat mass. In addition, similar beneficial metabolic effects were found in the children as shown in adults, e.g. increase in peripheral insulin sensitivity.

trial registrationClinicaltrials.gov Identifier number NCT01660789.

Indexed as

Blood GlucoseBody Fat DistributionBody Mass IndexChildCounselingDenmarkDiet, ReducingExercise TherapyFemaleHumansInsulinMaleObesityOverweightPhysical FitnessWaist-Hip RatioBlood GlucoseInsulin

Identifiers

PMID25330848
PMCPMC4287468
OpenAlexW2128970844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.