ArticleMolecular psychiatry2016
Temporal variability of glucocorticoid receptor activity is functionally important for the therapeutic action of fluoxetine in the hippocampus.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Epigenetic landscapes of classical psychedelics and ketamine: molecular mechanisms of long-lasting neuromodulation.Molecular psychiatry · 2026Review
- A Vortioxetine-Glycyrrhizic Acid Supramolecular Complex: Synthesis and Cellular Effects on Microglial and Blood Cells Under Inflammatory and Glucocorticoid Challenge.Biomedicines · 2026Article
- Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Altered small-world property of a dynamic metabolic network in murine left hippocampus after exposure to acute stress.Scientific reports · 2022Article
- Ketamine, but not fluoxetine, rapidly rescues corticosterone-induced impairments on glucocorticoid receptor and dendritic branching in the hippocampus of mice.Metabolic brain disease · 2021Article
- Decoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior.Molecular psychiatry · 2021Article
- Single neonatal dexamethasone administration has long-lasting outcome on depressive-like behaviour, Bdnf, Nt-3, p75ngfr and sorting receptors (SorCS1-3) stress reactive expression.Scientific reports · 2021Article
- Experience and activity-dependent control of glucocorticoid receptors during the stress response in large-scale brain networks.Stress (Amsterdam, Netherlands) · 2021Article
- Pharmacological Treatment of Anxiety Disorders: The Role of the HPA Axis.Frontiers in psychiatry · 2020Review
- Persistence of learning-induced synapses depends on neurotrophic priming of glucocorticoid receptors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Improved dynamic monitoring of transcriptional activity during longitudinal analysis in the mouse brain.Biology open · 2019Article
- Prefrontal cortical trkB, glucocorticoids, and their interactions in stress and developmental contexts.Neuroscience and biobehavioral reviews · 2018Review
- Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity.PLoS biology · 2017Article
- Glucocorticoid receptor action in metabolic and neuronal function.F1000Research · 2017Review
- Isolating biomarkers for symptomatic states: considering symptom-substrate chronometry.Molecular psychiatry · 2016Review
- Enzymatic Depletion of the Polysialic Acid Moiety Associated with the Neural Cell Adhesion Molecule Inhibits Antidepressant Efficacy.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress.Mediators of inflammation · 2016Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown inconsistent results regarding the actions of antidepressants on glucocorticoid receptor (GR) signalling. To resolve these inconsistencies, we used a lentiviral-based reporter system to directly monitor rat hippocampal GR activity during stress adaptation. Temporal GR activation was induced significantly by acute stress, as demonstrated by an increase in the intra-individual variability of the acute stress group compared with the variability of the non-stress group. However, the increased intra-individual variability was dampened by exposure to chronic stress, which was partly restored by fluoxetine treatment without affecting glucocorticoid secretion. Immobility in the forced-swim test was negatively correlated with the intra-individual variability, but was not correlated with the quantitative GR activity during fluoxetine therapy; this highlights the temporal variability in the neurobiological links between GR signalling and the therapeutic action of fluoxetine. Furthermore, we demonstrated sequential phosphorylation between GR (S224) and (S232) following fluoxetine treatment, showing a molecular basis for hormone-independent nuclear translocation and transcriptional enhancement. Collectively, these results suggest a neurobiological mechanism by which fluoxetine treatment confers resilience to the chronic stress-mediated attenuation of hypothalamic-pituitary-adrenal axis activity.
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