ArticleTransfusion2015
Metabolomics profile comparisons of irradiated and nonirradiated stored donor red blood cells.
Article in Transfusion, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of Different Red Blood Cell Storage Solutions and Conditions on Cell Function and Viability: A Systematic Review.Biomolecules · 2024Pooled it
- Red Blood Cell Transfusion Characteristics and Morbidity or Mortality in Very-Low-Birth-Weight Infants.JAMA network open · 2026Observational
- It's in your blood: The impact of age, sex, genetic factors and exposures on stored red blood cell metabolism.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2024Review
- Metabolomic signatures of ideal cardiovascular health in black adults.Scientific reports · 2024Article
- Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Study on the relationship between selenium and cadmium in diseased human lungs.Advances in redox research · 2023Article
- Untargeted metabolomics reveals that multiple reproductive toxicants are present at the endometrium.The Science of the total environment · 2022Article
- Integrative interactomics applied to bovine fescue toxicosis.Scientific reports · 2022Article
- Plasma Metabolomics of Intermediate and Neovascular Age-Related Macular Degeneration Patients.Cells · 2021Article
- Systemic Effects of Radiotherapy and Concurrent Chemo-Radiotherapy in Head and Neck Cancer Patients-Comparison of Serum Metabolome Profiles.Metabolites · 2020Article
- A precision medicine approach to defining the impact of doxorubicin on the bioenergetic-metabolite interactome in human platelets.Redox biology · 2020Article
- Metabolome-Wide Association Study of Deployment to Balad, Iraq or Bagram, Afghanistan.Journal of occupational and environmental medicine · 2019Article
- Environmental Chemicals Altered in Association With Deployment for High Risk Areas.Journal of occupational and environmental medicine · 2019Article
- Associations of Benzo(ghi)perylene and Heptachlorodibenzo-p-dioxin in Serum of Service Personnel Deployed to Balad, Iraq, and Bagram, Afghanistan Correlates With Perturbed Amino Acid Metabolism in Human Lung Fibroblasts.Journal of occupational and environmental medicine · 2019Article
- Analysis of Postdeployment Serum Samples Identifies Potential Biomarkers of Exposure to Burn Pits and Other Environmental Hazards.Journal of occupational and environmental medicine · 2019Article
- Benzo[a]pyrene Perturbs Mitochondrial and Amino Acid Metabolism in Lung Epithelial Cells and Has Similar Correlations With Metabolic Changes in Human Serum.Journal of occupational and environmental medicine · 2019Article
- Arginine and Carnitine Metabolites Are Altered in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2019Article
- Mitochondria in precision medicine; linking bioenergetics and metabolomics in platelets.Redox biology · 2019Article
- The Carnitine Shuttle Pathway is Altered in Patients With Neovascular Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundUnderstanding the metabolites that are altered by donor red blood cell (RBC) storage and irradiation may provide insight into the metabolic pathways disrupted by the RBC storage lesion. STUDY DESIGN AND
methodsPatterns of metabolites, representing more than 11,000 distinct mass-to-charge ratio (m/z) features, were compared between gamma-irradiated and nonirradiated CPDA-1-split RBCs from six human donors over 35 days of storage using multilevel sparse partial least squares discriminant analysis (msPLSDA), hierarchical clustering, pathway enrichment analysis, and network analysis.
resultsIn msPLSDA analysis, RBC units stored 7 days or fewer (irradiated or nonirradiated) showed similar metabolomic profiles. By contrast, donor RBCs stored 10 days or more demonstrated distinct clustering as a function of storage time and irradiation. Irradiation shifted metabolic features to those seen in older units. Hierarchical clustering analysis identified at least two clusters of metabolites that differentiated between RBC units based on storage time and irradiation exposure, confirming results of the msPLSDA analysis. Pathway enrichment analysis, used to map the discriminatory biochemical features to specific metabolic pathways, identified four pathways significantly affected by irradiation and/or storage including arachidonic acid (p = 3.3 × 10(-33)) and linoleic acid (p = 1.61 × 10(-11)) metabolism.
conclusionRBC storage under blood bank conditions produces numerous metabolic alterations. Gamma irradiation accentuates these differences as the age of blood increases, indicating that at the biochemical level irradiation accelerates metabolic aging of stored RBCs. Metabolites involved in the cellular membrane are prominently affected and may be useful biomarkers of the RBC storage lesion.
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Registered trials
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