ArticleJournal of the American Chemical Society2014
Unraveling the biomolecular snapshots of mitosis in healthy and cancer cells using plasmonically-enhanced Raman spectroscopy.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 83 citations in OpenAlex.
- Integrated characterization of extracellular matrix remodeling in Candida parapsilosis biofilms by surface-enhanced raman spectroscopy, protein analysis, ultrastructural imaging and multivariate analysis.World journal of microbiology & biotechnology · 2026Article
- Programmed cell death and redox metabolism protect Chlamydomonas reinhardtii populations from the galactic cosmic environment on the Artemis-1 mission.Scientific reports · 2025Article
- Harnessing the Power of Plasmonics forACS photonics · 2025Review
- Nanoplasmonic biosensors for environmental sustainability and human health.Chemical Society reviews · 2024Review
- Real-time monitoring of single dendritic cell maturation using deep learning-assisted surface-enhanced Raman spectroscopy.Theranostics · 2024Article
- Enhanced Tumor Accumulation of Multimodal Magneto-Plasmonic Nanoparticles via an Implanted Micromagnet-Assisted Delivery Strategy.Advanced healthcare materials · 2023Article
- High Uniformity and Enhancement Au@AgNS 3D Substrates for the Diagnosis of Breast Cancer.ACS omega · 2022Article
- Live Cell Poration by Au Nanostars to Probe Intracellular Molecular Composition with SERS.Nanomaterials (Basel, Switzerland) · 2021Article
- Effects of macrophage polarization on gold nanoparticle-assisted plasmonic photothermal therapy.RSC advances · 2021Article
- Furin-Mediated Self-Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors.Angewandte Chemie (International ed. in English) · 2021Article
- Bioapplications of Nanomaterials.Advances in experimental medicine and biology · 2021Article
- Present and Future of Surface-Enhanced Raman Scattering.ACS nano · 2020Article
- Monitoring the dynamics of hemeoxygenase-1 activation in head and neck cancer cells in real-time using plasmonically enhanced Raman spectroscopy.Chemical science · 2019Article
- Bone quality assessment of osteogenic cell cultures by Raman microscopy.Journal of Raman spectroscopy : JRS · 2019Article
- Nuclear Membrane-Targeted Gold Nanoparticles Inhibit Cancer Cell Migration and Invasion.ACS nano · 2017Article
- Investigating the Origins of Toxic Response in TiO₂ Nanoparticle-Treated Cells.Nanomaterials (Basel, Switzerland) · 2017Article
- Plasmon-enhanced Raman spectroscopic metrics forChemical science · 2017Article
- Raman spectroscopy and regenerative medicine: a review.NPJ Regenerative medicine · 2017Review
- Elucidation of ultraviolet radiation-induced cell responses and intracellular biomolecular dynamics in mammalian cells using surface-enhanced Raman spectroscopy.Chemical science · 2016Article
- Prof. Mostafa A El-Sayed andNanobiomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Owing to the dynamic and complex nature of mitosis, precise and timely executions of biomolecular events are critical for high fidelity cell division. In this context, visualization of such complex events at the molecular level can provide vital information on the biomolecular processes in abnormal cells. Here, we explored the plasmonically enhanced light scattering properties of functionalized gold nanocubes (AuNCs) together with surface-enhanced Raman spectroscopy (SERS) to unravel the complex and dynamic biological processes involved in mitosis of healthy and cancerous cells from its molecular perspectives. By monitoring various stages of mitosis using SERS, we noticed that relatively high rate of conversion of mitotic proteins from their α-helix structure to β-sheet conformation is likely in the cancer cells during meta-, ana-, and telophases. Unique biochemical modifications to the lipid and amino acid moieties, associated with the observed protein conformational modifications, were also identified. However, in healthy cells, the existence of proteins in their β conformation was momentary and was largely in the α-helix form. The role of abnormal conformational modifications of mitotic proteins on the development of anomalous mitotic activities was further confirmed by looking at plasmonic nanoparticle-induced cytokinesis failure in cancer cells. Our findings illustrate the vast possibilities of SERS in real-time tracking of complex, subtle, and momentary modifications of biomolecules in live cells, which could provide new insights to the role of protein conformation dynamics during mitosis on the development of cancer and many other diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.