Evidence map›Paper›PMID 25329926›Full record

ArticleChemical communications (Cambridge, England)2015

Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces.

Joe E Baio, Denise Schach, Adrian V Fuchs, Lars Schmüser, Nils Billecke, Christoph Bubeck, Katharina Landfester, Mischa Bonn, Michael Bruns, Clemens K Weiss and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure.Journal of visualized experiments : JoVE · 2021
    Article
  2. Article
  3. Evidence of a molecular boundary lubricant at snakeskin surfaces.Journal of the Royal Society, Interface · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Joe E Baio *Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
Denise Schach *Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
Adrian V FuchsMax Planck Institute for Polymer Research, 55270 Mainz, Germany.
Lars SchmüserMax Planck Institute for Polymer Research, 55270 Mainz, Germany.
Nils BilleckeMax Planck Institute for Polymer Research, 55270 Mainz, Germany.
Christoph BubeckMax Planck Institute for Polymer Research, 55270 Mainz, Germany.
Katharina LandfesterMax Planck Institute for Polymer Research, 55270 Mainz, Germany.
Mischa BonnMax Planck Institute for Polymer Research, 55270 Mainz, Germany.
Michael BrunsKarlsruhe Institute of Technology, Institute for Applied Materials and Karlsruhe Nano Micro Facility, 76344 Eggenstein-Leopoldshafen, Germany.
Clemens K WeissMax Planck Institute for Polymer Research, 55270 Mainz, Germany.
Tobias WeidnerMax Planck Institute for Polymer Research, 55270 Mainz, Germany.
Max Planck Institute for Polymer Research · DEUniversity of Applied Sciences Mainz · DEKarlsruhe Institute of Technology · DE

Funding

Surface Analysis Facility for Biomedical ProblemsP41EB002027 · NIBIB · UNIVERSITY OF WASHINGTON · PI CASTNER, DAVID G, GAMBLE, LARA · 2003 to 2019
$17.6M
NIBIB NIH HHS P41 EB002027
6 · The paper itself

Abstract

pH-sensitive viral fusion protein mimics are widely touted as a promising route towards site-specific delivery of therapeutic compounds across lipid membranes. Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retains its functionality when covalently bound to a surface.

Indexed as

Amino Acid SequenceCell-Penetrating PeptidesGoldHydrogen-Ion ConcentrationImmobilized ProteinsMetal NanoparticlesModels, MolecularMolecular Sequence DataPeptidesProtein Structure, SecondarySurface PropertiesCell-Penetrating PeptidesGALA peptideGoldImmobilized ProteinsPeptides

Identifiers

PMID25329926
PMCPMC4608256
OpenAlexW2116677799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.