SynthesisBipolar disorders2015
International Society for Bipolar Disorders Task Force on Suicide: meta-analyses and meta-regression of correlates of suicide attempts and suicide deaths in bipolar disorder.
Synthesis in Bipolar disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
106 citing papers in PubMed, 11 syntheses or guidelines pooled it, 328 citations in OpenAlex.
- Boulevard of broken rhythms: A systematic review and meta-analysis on the relationship between sleep disturbances and suicidal behavior in bipolar disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Suicidality risk after using cannabis and cannabinoids: An umbrella review.Dialogues in clinical neuroscience · 2023Pooled it
- All-cause and cause-specific mortality among people with bipolar disorder: a large-scale systematic review and meta-analysis.Molecular psychiatry · 2023Pooled it
- Associations of migraines with suicide ideation or attempts: A meta-analysis.Frontiers in public health · 2023Pooled it
- Comparison of the efficacy and safety of quetiapine and lithium for bipolar depression: A systematic review and meta-analysis of randomized controlled trials.Neuropsychopharmacology reports · 2022Pooled it
- Systematic Review and Meta-Analysis on MS-Based Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Bipolar Disorder.International journal of molecular sciences · 2022Pooled it
- Suicides in Mood Disorders in Psychiatric Settings in Nordic National Register-Based Studies.Frontiers in psychiatry · 2020Pooled it
- Prevalence of suicide attempts in bipolar disorder: a systematic review and meta-analysis of observational studies.Epidemiology and psychiatric sciences · 2019Pooled it
- Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder.Bipolar disorders · 2018Guideline
- History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Pooled it
- A review of factors associated with greater likelihood of suicide attempts and suicide deaths in bipolar disorder: Part II of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder.The Australian and New Zealand journal of psychiatry · 2015Pooled it
- Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-On Trial Treatment for Acute Bipolar Depression Patients With Suicidal Ideation.CNS neuroscience & therapeutics · 2024Trial
- Acute risk factors for suicide attempts and death: prospective findings from the STEP-BD study.Bipolar disorders · 2016Trial
- Diagnosis-Specific Clinical and Longitudinal Predictors of Suicide Attempts in Early-Onset Mood Disorders.Psychiatry investigation · 2026Article
- Candidate Biomarkers of Bipolar Disorder Progression: Implications for Ketamine and Psychedelic Interventions.Molecular neurobiology · 2026Review
- Bipolar Disorder VI: Long-Term Follow-Up of Suicide Attempts and Prophylactic Effect of Lithium Treatment in Bipolar Affective Disorder.Biological psychiatry global open science · 2026Article
- Trajectories of Suicidal Risk Impact Mood Regulation Differently in Patients With a Diagnosis of Bipolar Disorder.Acta psychiatrica Scandinavica · 2026Article
- Calm after the storm? Clinical phenotypes and risk markers in suicidal patients: data from a liaison-consultation psychiatric setting.Frontiers in psychiatry · 2026Article
- Lithium restores inhibitory function and neuronal excitability through GSK-3β inhibition in a bipolar disorder-associated Ank3 variant mouse model.Neuropharmacology · 2025Article
- Neuroendocrine abnormalities as predictors of suicidal ideation in bipolar disorder patients during depressive episodes: a cross-sectional study.BMC psychiatry · 2025Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 19 institutions in 10 countries.
Funding
Abstract
objectivesBipolar disorder is associated with a high risk of suicide attempts and suicide death. The main objective of the present study was to identify and quantify the demographic and clinical correlates of attempted and completed suicide in people with bipolar disorder.
methodsWithin the framework of the International Society for Bipolar Disorders Task Force on Suicide, a systematic review of articles published since 1980, characterized by the key terms bipolar disorder and 'suicide attempts' or 'suicide', was conducted, and data extracted for analysis from all eligible articles. Demographic and clinical variables for which ≥ 3 studies with usable data were available were meta-analyzed using fixed or random-effects models for association with suicide attempts and suicide deaths. There was considerable heterogeneity in the methods employed by the included studies.
resultsVariables significantly associated with suicide attempts were: female gender, younger age at illness onset, depressive polarity of first illness episode, depressive polarity of current or most recent episode, comorbid anxiety disorder, any comorbid substance use disorder, alcohol use disorder, any illicit substance use, comorbid cluster B/borderline personality disorder, and first-degree family history of suicide. Suicide deaths were significantly associated with male gender and first-degree family history of suicide.
conclusionsThis paper reports on the presence and magnitude of the correlates of suicide attempts and suicide deaths in bipolar disorder. These findings do not address causation, and the heterogeneity of data sources should limit the direct clinical ranking of correlates. Our results nonetheless support the notion of incorporating diagnosis-specific data in the development of models of understanding suicide in bipolar disorder.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.