Evidence map›Paper›PMID 25329710›Full record

ArticleAIDS patient care and STDs2014

Timing of antiretroviral therapy initiation in a nationally representative sample of HIV-infected adults receiving medical care in the United States.

Demilade A Adedinsewo, Stanley C Wei, McKaylee Robertson, Charles Rose, Christopher H Johnson, Julie Dombrowski, Jacek Skarbinski

Abstract read
In one paragraph

Article in AIDS patient care and STDs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  11. Timing of Linkage to Care After HIV Diagnosis and Time to Viral Suppression.Journal of acquired immune deficiency syndromes (1999) · 2016
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Demilade A Adedinsewo1 Oak Ridge Institute for Science and Education , Oak Ridge, Tennessee.
Stanley C Wei
McKaylee Robertson
Charles Rose
Christopher H Johnson
Julie Dombrowski
Jacek Skarbinski

Funding

Clinic and Population-Based Approaches to Retention in HIV CareK23MH090923 · NIMH · UNIVERSITY OF WASHINGTON · PI DOMBROWSKI, JULIA COOK · 2010 to 2014
$657k
NCHHSTP CDC HHS PS09-937NIMH NIH HHS K23 MH090923NIMH NIH HHS L30 MH095060
6 · The paper itself

Abstract

Early antiretroviral therapy (ART) initiation reduces the risk of disease progression and HIV transmission, but data on time from HIV care entry to ART initiation are lacking. Using data from the Medical Monitoring Project (MMP), a population-based probability sample of HIV-infected adults receiving medical care in the United States, we assessed time from care entry to ART initiation among persons diagnosed May 2004-April 2009 and used multivariable Cox proportional-hazards models to identify factors associated with time to ART initiation. Among 1094 MMP participants, 83.9% reported initiating ART, with median time to ART initiation of 10 months. In multivariable models, blacks compared to whites [hazard ratio (HR) 0.82; 95% confidence interval (CI) 0.70-0.98], persons without continuous health insurance (HR 0.82; CI 0.70-0.97), heterosexual women and men who have sex with men compared to heterosexual men (HR 0.66; CI 0.51-0.85 and HR 0.71; CI 0.60-0.84, respectively), and persons without AIDS at care entry (HR 0.37; CI 0.31-0.43) had significantly longer times to ART initiation. Overall, time to ART initiation was suboptimal by current standards and significant disparities were noted among certain subgroups. Efforts to encourage prompt ART initiation should address delays among those without health insurance and among certain sociodemographic subgroups.

Indexed as

Patient Acceptance of Health CareSexual BehaviorTime-to-TreatmentAdolescentAdultAnti-HIV AgentsAnti-Retroviral AgentsCD4 Lymphocyte CountCross-Sectional StudiesFemaleHIV InfectionsHumansIncidenceInsurance CoverageInterviews as TopicKaplan-Meier EstimateAnti-HIV AgentsAnti-Retroviral Agents

Identifiers

PMID25329710
PMCPMC4250960

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.