ArticleThe Journal of clinical investigation2014
sFLT1 in preeclampsia: trophoblast defense against a decidual VEGFA barrage?
Article in The Journal of clinical investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Divide-and-conquer analysis reveals hidden immune cell influencers across the placenta in preeclampsia.BioData mining · 2026Article
- Vascular Dysfunction in Preeclampsia.Cells · 2021Review
- Angiogenic factors, bladder neuroplasticity and interstitial cystitis-new pathobiological insights.Translational andrology and urology · 2015Review
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1 author at 1 institution in 1 country.
Funding
Abstract
Preeclampsia, a life-threatening complication of human pregnancy, has a spectrum of clinical signs and is likely caused by an array of pathological mechanisms. However, elevated levels of soluble fms-like tyrosine kinase-1 (sFLT1) in the placenta and in the maternal circulation has emerged as a common finding in women with preeclampsia and likely is a causative factor in this disorder. In this issue of the JCI, Fan and colleagues provide experimental evidence from both humans and mice that suggests placental trophoblast cells overexpress sFLT1 in self defense against excessive VEGFA produced by maternal decidual cells. The authors' work thus implicates the decidual cells of the mother as the culprit responsible for increased placental expression of sFLT1, a VEGFA antagonist that enters the maternal circulation and consequently induces the clinical signs of preeclampsia.
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Registered trials
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