Evidence map›Paper›PMID 25329677›Full record

ArticlePloS one2014

Upregulation of autophagy-related gene-5 (ATG-5) is associated with chemoresistance in human gastric cancer.

Jie Ge, Zihua Chen, Jin Huang, Jinxiang Chen, Weijie Yuan, Zhenghao Deng, Zhikang Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 106 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jie GeDepartment of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Zihua ChenDepartment of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Jin HuangDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Jinxiang ChenDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Weijie YuanDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Zhenghao DengDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Zhikang ChenDepartment of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy-related gene-5 (ATG-5) is one of the key regulators of autophagic cell death. It has been widely regarded as a protective molecular mechanism for tumor cells during the course of chemotherapy. In the present study, we investigated the expression pattern of ATG-5 and multidrug resistance-associated protein-1 (MRP-1) in 135 gastric cancers (GC) patients who were treated with epirubicin, cisplatin and 5-FU adjuvant chemotherapy (ECF) following surgical resection and explored their potential clinical significance. We found that both ATG-5 (77.78%) and MRP-1 (79.26%) were highly expressed in GC patients. ATG-5 expression was significantly associated with depth of wall invasion, TNM stages and distant metastasis of GC (P<0.05), whereas MRP-1 expression was significantly linked with tumor size, depth of wall invasion, lymph node metastasis, TNM stages and differentiation status (P<0.05). ATG-5 expression was positively correlated with MRP-1 (rp = 0.616, P<0.01). Increased expression of ATG-5 and MPR-1 was significantly correlated with poor overall survival (OS; P<0.01) and disease free survival (DFS; P<0.01) of our GC cohort. Furthermore, we demonstrated that ATG-5 was involved in drug resistant of GC cells, which was mainly through regulating autophagy. Our data suggest that upregulated expression of ATG-5, an important molecular feature of protective autophagy, is associated with chemoresistance in GC. Expression of ATG-5 and MRP-1 may be independent prognostic markers for GC treatment.

Indexed as

Up-RegulationAdultAgedATP-Binding Cassette, Sub-Family C ProteinsAutophagy-Related Protein 5Disease-Free SurvivalDrug Resistance, NeoplasmFemaleHumansMaleMicrotubule-Associated ProteinsMiddle AgedStomach NeoplasmsATG5 protein, humanATP-Binding Cassette, Sub-Family C ProteinsAutophagy-Related Protein 5Microtubule-Associated Proteinsmultidrug resistance-associated protein 1

Identifiers

PMID25329677
PMCPMC4201506
OpenAlexW2043538870

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.