Evidence map›Paper›PMID 25329655›Full record

ArticlePloS one2014

CT perfusion imaging as an early biomarker of differential response to stereotactic radiosurgery in C6 rat gliomas.

Timothy Pok Chi Yeung, Maher Kurdi, Yong Wang, Baraa Al-Khazraji, Laura Morrison, Lisa Hoffman, Dwayne Jackson, Cathie Crukley, Ting-Yim Lee, Glenn Bauman and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Assessment of the Validity of Carbon Ion Irradiation for C6 Gliomas in Rats.Dose-response : a publication of International Hormesis Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Timothy Pok Chi YeungDepartment of Medical Biophysics, Western University, London, Ontario, Canada; Robarts Research Institute, Western University, London, Ontario, Canada; London Regional Cancer Program, London, Ontario, Canada.
Maher KurdiDepartment of Pathology, Western University, London, Ontario, Canada; Department of Pathology, King Abdulaziz University, Jeddah, Makkah, Saudi Arabia.
Yong WangRobarts Research Institute, Western University, London, Ontario, Canada.
Baraa Al-KhazrajiDepartment of Medical Biophysics, Western University, London, Ontario, Canada.
Laura MorrisonLawson Imaging, Lawson Health Research Institute, London, Ontario, Canada.
Lisa HoffmanDepartment of Medical Biophysics, Western University, London, Ontario, Canada; Department of Anatomy and Cell Biology, Western University, London, Ontario, Canada; Lawson Imaging, Lawson Health Research Institute, London, Ontario, Canada.
Dwayne JacksonDepartment of Medical Biophysics, Western University, London, Ontario, Canada.
Cathie CrukleyRobarts Research Institute, Western University, London, Ontario, Canada.
Ting-Yim LeeDepartment of Medical Biophysics, Western University, London, Ontario, Canada; Robarts Research Institute, Western University, London, Ontario, Canada; Lawson Imaging, Lawson Health Research Institute, London, Ontario, Canada; Department of Medical Imaging, Western University, London, Ontario, Canada; Department of Oncology, Western University, London, Ontario, Canada.
Glenn BaumanDepartment of Medical Biophysics, Western University, London, Ontario, Canada; Department of Oncology, Western University, London, Ontario, Canada; London Regional Cancer Program, London, Ontario, Canada.
Slav YartsevDepartment of Medical Biophysics, Western University, London, Ontario, Canada; Department of Oncology, Western University, London, Ontario, Canada; London Regional Cancer Program, London, Ontario, Canada.

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

backgroundThe therapeutic efficacy of stereotactic radiosurgery for glioblastoma is not well understood, and there needs to be an effective biomarker to identify patients who might benefit from this treatment. This study investigated the efficacy of computed tomography (CT) perfusion imaging as an early imaging biomarker of response to stereotactic radiosurgery in a malignant rat glioma model.

methodsRats with orthotopic C6 glioma tumors received either mock irradiation (controls, N = 8) or stereotactic radiosurgery (N = 25, 12 Gy in one fraction) delivered by Helical Tomotherapy. Twelve irradiated animals were sacrificed four days after stereotactic radiosurgery to assess acute CT perfusion and histological changes, and 13 irradiated animals were used to study survival. Irradiated animals with survival >15 days were designated as responders while those with survival ≤15 days were non-responders. Longitudinal CT perfusion imaging was performed at baseline and regularly for eight weeks post-baseline.

resultsEarly signs of radiation-induced injury were observed on histology. There was an overall survival benefit following stereotactic radiosurgery when compared to the controls (log-rank P<0.04). Responders to stereotactic radiosurgery showed lower relative blood volume (rBV), and permeability-surface area (PS) product on day 7 post-stereotactic radiosurgery when compared to controls and non-responders (P<0.05). rBV and PS on day 7 showed correlations with overall survival (P<0.05), and were predictive of survival with 92% accuracy.

conclusionsResponse to stereotactic radiosurgery was heterogeneous, and early selection of responders and non-responders was possible using CT perfusion imaging. Validation of CT perfusion indices for response assessment is necessary before clinical implementation.

Indexed as

Perfusion ImagingTomography, Emission-ComputedAnimalsBrain NeoplasmsGliomaMaleRadiation InjuriesRadiosurgeryRatsRats, Wistar

Identifiers

PMID25329655
PMCPMC4201465

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.