ArticlePLoS genetics2014
Basement membrane and cell integrity of self-tissues in maintaining Drosophila immunological tolerance.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- RPAP3: Structural evolution, chaperone networks, and disease implications of a transcriptional Co-chaperone.The Journal of biological chemistry · 2026Review
- Functional Analysis ofInsects · 2026Article
- Multifaceted Defenses Against Parasitoid Wasps in Diptera.Annual review of genetics · 2025Review
- The matrix glycoprotein Papilin maintains the haematopoietic progenitor pool in Drosophila lymph glands.Development (Cambridge, England) · 2025Article
- Anopheles gambiae phagocytic hemocytes promote Plasmodium falciparum infection by regulating midgut epithelial integrity.Nature communications · 2025Article
- Mitochondrial AAAFrontiers in cell and developmental biology · 2025Article
- Recognition of nonself is necessary to activate Drosophila's immune response against an insect parasite.BMC biology · 2024Article
- Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila.BMC biology · 2024Article
- MicroRNA miR-274-5p SuppressesInsects · 2023Article
- Drosophila hemocytes recognize lymph gland tumors of mxc mutants and activate the innate immune pathway in a reactive oxygen species-dependent manner.Biology open · 2022Article
- Extracellular matrix protein N-glycosylation mediates immune self-tolerance inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Anti-Fibrotic Activity of an Antimicrobial Peptide in a Drosophila Model.Journal of innate immunity · 2021Article
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- Discovery of aspirin-triggered eicosanoid-like mediators in aJournal of cell science · 2019Article
- Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours inDisease models & mechanisms · 2019Article
- Review
- Dissection of Nidogen function in Drosophila reveals tissue-specific mechanisms of basement membrane assembly.PLoS genetics · 2018Article
- Article
- Sterile inflammation in Drosophila.Mediators of inflammation · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism underlying immune system recognition of different types of pathogens has been extensively studied over the past few decades; however, the mechanism by which healthy self-tissue evades an attack by its own immune system is less well-understood. Here, we established an autoimmune model of melanotic mass formation in Drosophila by genetically disrupting the basement membrane. We found that the basement membrane endows otherwise susceptible target tissues with self-tolerance that prevents autoimmunity, and further demonstrated that laminin is a key component for both structural maintenance and the self-tolerance checkpoint function of the basement membrane. Moreover, we found that cell integrity, as determined by cell-cell interaction and apicobasal polarity, functions as a second discrete checkpoint. Target tissues became vulnerable to blood cell encapsulation and subsequent melanization only after loss of both the basement membrane and cell integrity.
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