ArticlePLoS genetics2014
White cells facilitate opposite- and same-sex mating of opaque cells in Candida albicans.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- Article
- Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways.Science China. Life sciences · 2023Article
- Glucose depletion enables Candida albicans mating independently of the epigenetic white-opaque switch.Nature communications · 2023Article
- Epistatic genetic interactions govern morphogenesis during sexual reproduction and infection in a global human fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- Unraveling HowJournal of fungi (Basel, Switzerland) · 2020Review
- Genetic regulation of the development of mating projections inEmerging microbes & infections · 2020Article
- Environment-induced same-sex mating in the yeast Candida albicans through the Hsf1-Hsp90 pathway.PLoS biology · 2019Article
- A coupled process of same- and opposite-sex mating generates polyploidy and genetic diversity in Candida tropicalis.PLoS genetics · 2018Article
- Genome-wide functional analysis in Candida albicans.Virulence · 2017Review
- Metabolic Interactions between Bacteria and Fungi in Commensal Oral Biofilms.Journal of fungi (Basel, Switzerland) · 2017Review
- Article
- Discovery of the gray phenotype and white-gray-opaque tristable phenotypic transitions in Candida dubliniensis.Virulence · 2016Article
- The Regulatory Subunit of Protein Kinase A (Bcy1) inFrontiers in microbiology · 2016Article
- The parasexual lifestyle of Candida albicans.Current opinion in microbiology · 2015Review
- pH Regulates White-Opaque Switching and Sexual Mating in Candida albicans.Eukaryotic cell · 2015Article
- Editorial overview: host-microbe interactions: fungi: heterogeneity in fungal cells, populations, and communities.Current opinion in microbiology · 2015Article
- Candida albicans the chameleon: transitions and interactions between multiple phenotypic states confer phenotypic plasticity.Current opinion in microbiology · 2015Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Modes of sexual reproduction in eukaryotic organisms are extremely diverse. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to become mating-competent. In this study, we report that functionally- and morphologically-differentiated white and opaque cells show a coordinated behavior during mating. Although white cells are mating-incompetent, they can produce sexual pheromones when treated with pheromones of the opposite mating type or by physically interacting with opaque cells of the opposite mating type. In a co-culture system, pheromones released by white cells induce opaque cells to form mating projections, and facilitate both opposite- and same-sex mating of opaque cells. Deletion of genes encoding the pheromone precursor proteins and inactivation of the pheromone response signaling pathway (Ste2-MAPK-Cph1) impair the promoting role of white cells (MTLa) in the sexual mating of opaque cells. White and opaque cells communicate via a paracrine pheromone signaling system, creating an environment conducive to sexual mating. This coordination between the two different cell types may be a trade-off strategy between sexual and asexual lifestyles in C. albicans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.