Evidence map›Paper›PMID 25329498›Full record

ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2015

Early divergence of central and peripheral neural retina precursors during vertebrate eye development.

Sara J Venters, Takashi Mikawa, Jeanette Hyer

Abstract readReview
In one paragraph

Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Mettl14-mediated mCell reports · 2023
    Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sara J VentersCardiovascular Research Institute, University of California, San Francisco, California; Department of Neurosurgery, University of California, San Francisco San Francisco, California.
Takashi Mikawa
Jeanette Hyer

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8M
Coronary Vascular Cell DevelopmentR37HL078921 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIKAWA, TAKASHI · 2010 to 2019
$3.8M
Specification &development of ciliary body epitheliumR01EY015429 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HYER, JEANETTE · 2004 to 2010
$2.1M
Cardiac Pacemaker DevelopmentR01HL112268 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIKAWA, TAKASHI · 2012 to 2016
$1.9M
Heart Field DevelopmentR01HL122375 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIKAWA, TAKASHI · 2014 to 2017
$1.6M
NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY015429NHLBI NIH HHS R01 HL112268NHLBI NIH HHS R01HL112268NHLBI NIH HHS R01 HL122375NHLBI NIH HHS R37 HL078921
6 · The paper itself

Abstract

backgroundDuring development of the vertebrate eye, optic tissue is progressively compartmentalized into functionally distinct tissues. From the central to the peripheral optic cup, the original optic neuroepithelial tissue compartmentalizes, forming retina, ciliary body, and iris. The retina can be further sub-divided into peripheral and central compartments, where the central domain is specialized for higher visual acuity, having a higher ratio and density of cone photoreceptors in most species.

resultsClassically, models depict a segregation of the early optic cup into only two domains, neural and non-neural. Recent studies, however, uncovered discrete precursors for central and peripheral retina in the optic vesicle, indicating that the neural retina cannot be considered as a single unit with homogeneous specification and development. Instead, central and peripheral retina may be subject to distinct developmental pathways that underlie their specialization.

conclusionsThis review focuses on lineage relationships in the retina and revisits the historical context for segregation of central and peripheral retina precursors before overt eye morphogenesis.

Indexed as

AnimalsHumansOrganogenesisRetinaStem Cellsavian eyefate maplineageoptic cupoptic vesicle

Identifiers

PMID25329498
PMCPMC4351783

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.