Evidence map›Paper›PMID 25329408›Full record

ReviewNature reviews. Microbiology2014

Asymptomatic malaria infections: detectability, transmissibility and public health relevance.

Teun Bousema, Lucy Okell, Ingrid Felger, Chris Drakeley

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 448 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
448citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04167566 nacompletednot on this mapstarted 2017, after this paper: background citation

Exploring the Impact of Scaling up Mass Testing, Treatment and Tracking on Malaria Prevalence Among Children in the Pakro Sub District of Ghana

TypeinterventionalSponsorNoguchi Memorial Institute for Medical ResearchRan2017 to 2019Enrolled5,000ConditionsMalaria, Malaria, Asymptomatic ParasitaemiaArmsArtemisinin Combination Therapy ACTs
NCT04301531 nacompletednot on this mapstarted 2020, after this paper: background citation

Determining the Impact of Scaling up Mass Testing, Treatment and Tracking on Malaria Prevalence Among Children in the Pakro Sub District of Ghana

TypeinterventionalSponsorNoguchi Memorial Institute for Medical ResearchRan2020 to 2023Enrolled5,861ConditionsMalaria Asymptomatic ParasitaemiaArmsMass testing using RDTs, Treatment for all cases confirmed positive malaria cases with ACTs, Determination of Hb, Household survey, Community-base management of malaria
NCT07358767 nacompletednot on this mapstarted 2021, after this paper: background citation

Determining the Impact of Malaria Mass Drug Administration on Malaria Prevalence in Under 15 Children and Pregnant Women

TypeinterventionalSponsorNoguchi Memorial Institute for Medical ResearchRan2021 to 2023Enrolled3,300ConditionsMalariaArmsArtemether-lumefantrine (AL)
3 · Its place in the literature

Who cites it

448 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  5. Ivermectin treatment in humans for reducing malaria transmission.The Cochrane database of systematic reviews · 2021
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388 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Teun Bousema1] London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK. [2] Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.
Lucy OkellImperial College, London, London SW7 2AZ, UK.
Ingrid FelgerSwiss Tropical Institute, 4051 Basel, Switzerland.
Chris DrakeleyLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

Funding

Medical Research Council G1002387Medical Research Council MR/K010174/1
6 · The paper itself

Abstract

Most Plasmodium falciparum infections that are detected in community surveys are characterized by low-density parasitaemia and the absence of clinical symptoms. Molecular diagnostics have shown that this asymptomatic parasitic reservoir is more widespread than previously thought, even in low-endemic areas. In this Opinion article, we describe the detectability of asymptomatic malaria infections and the relevance of submicroscopic infections for parasite transmission to mosquitoes and for community interventions that aim at reducing transmission. We argue that wider deployment of molecular diagnostic tools is needed to provide adequate insight into the epidemiology of malaria and infection dynamics to aid elimination efforts.

Indexed as

Public HealthAnimalsAsymptomatic InfectionsCulicidaeDisease ReservoirsFemaleHumansInsect VectorsMalaria, FalciparumMaleParasitemiaPlasmodium falciparumPolymerase Chain ReactionPrevalence

Identifiers

PMID25329408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.