Trial reportPloS one2014
Impact of exercise and moderate hypoxia on glycemic regulation and substrate oxidation pattern.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The impact of hypoxia exposure on glucose homeostasis in metabolically compromised humans: A systematic review.Reviews in endocrine & metabolic disorders · 2021Pooled it
- The effects of environmental hypoxia on substrate utilisation during exercise: a meta-analysis.Journal of the International Society of Sports Nutrition · 2019Pooled it
- Carbohydrate supplementation and psychophysiological responses during moderate exercise in hypoxia.Journal of the International Society of Sports Nutrition · 2020Trial
- Effects of High-Intensity Interval Training with Blood Flow Restriction Versus Normobaric Hypoxia on Physiological Parameters in Apparently Healthy Young Men.Sports (Basel, Switzerland) · 2026Article
- Effects of exercise modality combined with moderate hypoxia on blood glucose regulation in adults with overweight.Frontiers in physiology · 2024Article
- Mechanisms for Combined Hypoxic Conditioning and Divergent Exercise Modes to Regulate Inflammation, Body Composition, Appetite, and Blood Glucose Homeostasis in Overweight and Obese Adults: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2023Review
- Mild intermittent hypoxia exposure induces metabolic and molecular adaptations in men with obesity.Molecular metabolism · 2021Article
- Is Physical Exercise in Hypoxia an Interesting Strategy to Prevent the Development of Type 2 Diabetes? A Narrative Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Review
- Effects of endurance exercise under hypoxia on acid-base and ion balance in healthy males.Physical activity and nutrition · 2020Article
- Exogenous glucose oxidation during endurance exercise in hypoxia.Physiological reports · 2020Article
- Endocrine and Metabolic Responses to Endurance Exercise Under Hot and Hypoxic Conditions.Frontiers in physiology · 2020Article
- Oxygenation of adipose tissue: A human perspective.Acta physiologica (Oxford, England) · 2020Review
- Substrate oxidation and the influence of breakfast in normobaric hypoxia and normoxia.European journal of applied physiology · 2019Article
- Effect of New Zealand Blackcurrant Extract on Cycling Performance and Substrate Oxidation in Normobaric Hypoxia in Trained Cyclists.Sports (Basel, Switzerland) · 2019Article
- Inflammatory, Oxidative Stress, and Angiogenic Growth Factor Responses to Repeated-Sprint Exercise in Hypoxia.Frontiers in physiology · 2019Article
- The Effects of Endurance Exercise in Hypoxia on Acid-Base Balance, Potassium Kinetics, and Exogenous Glucose Oxidation.Frontiers in physiology · 2019Article
- The effects of endurance exercise in hypoxia on acid-base balance and potassium kinetics: a randomized crossover design in male endurance athletes.Sports medicine - open · 2018Article
- Metabolic and Performance Responses to Sprint Exercise under Hypoxia among Female Athletes.Sports medicine international open · 2018Article
- Exercise timing and blood lactate concentrations in individuals with type 2 diabetes.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe examined metabolic and endocrine responses during rest and exercise in moderate hypoxia over a 7.5 h time courses during daytime.
methodsEight sedentary, overweight men (28.6 ± 0.8 kg/m2) completed four experimental trials: a rest trial in normoxia (FiO2 = 20.9%, NOR-Rest), an exercise trial in normoxia (NOR-Ex), a rest trial in hypoxia (FiO2 = 15.0%, HYP-Rest), and an exercise trial in hypoxia (HYP-Ex). Experimental trials were performed from 8:00 to 15:30 in an environmental chamber. Blood and respiratory gas samples were collected over 7.5 h. In the exercise trials, subjects performed 30 min of pedaling exercise at 60% of VO2max at 8:00, 10:30, and 13:00, and rested during the remaining period in each environment. Standard meals were provided at 8:30, 11:00, and 13:30.
resultsThe areas under the curves for blood glucose and serum insulin concentrations over 7.5 h did not differ among the four trials. At baseline, %carbohydrate contribution was significantly higher in the hypoxic trials than in the normoxic trials (P<0.05). Although exercise promoted carbohydrate oxidation in the NOR-Ex and HYP-Ex trials, %carbohydrate contribution during each exercise and post-exercise period were significantly higher in the HYP-Ex trial than in the NOR-Ex trial (P<0.05).
conclusionThree sessions of 30 min exercise (60% of VO2max) in moderate hypoxia over 7.5 h did not attenuate postprandial glucose and insulin responses in young, overweight men. However, carbohydrate oxidation was significantly enhanced when the exercise was conducted in moderate hypoxia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.