ArticleeLife2014
Non-linear developmental trajectory of electrical phenotype in rat substantia nigra pars compacta dopaminergic neurons.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Proteomic profiling across early postnatal development of midbrain dopamine axons innervating the dorsal striatum.bioRxiv : the preprint server for biology · 2026Article
- Article
- The effect of cannabinoid type Ⅱ receptor on the excitability of substantia nigra dopaminergic neurons.Frontiers in pharmacology · 2025Article
- Intrinsic and synaptic regulation of axonal excitability in dopaminergic neurons.Frontiers in cellular neuroscience · 2025Review
- Morphological Determinants of Cell-to-Cell Variations in Action Potential Dynamics in Substantia Nigra Dopaminergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Electrophysiological Properties of Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Neurons Correlate With Expression of Tyrosine Hydroxylase.Frontiers in cellular neuroscience · 2022Article
- Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters.Neurobiology of aging · 2020Article
- Moderate Changes in COiScience · 2020Article
- Methadone Suppresses Neuronal Function and Maturation in Human Cortical Organoids.Frontiers in neuroscience · 2020Article
- Dimensions of control for subthreshold oscillations and spontaneous firing in dopamine neurons.PLoS computational biology · 2019Article
- Robustness to Axon Initial Segment Variation Is Explained by Somatodendritic Excitability in Rat Substantia Nigra Dopaminergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Electrical Abnormalities in Dopaminergic Neurons of the Substantia Nigra in Mice With an Aromatic L-Amino Acid Decarboxylase Deficiency.Frontiers in cellular neuroscience · 2019Article
- Neurotransmitter identity and electrophysiological phenotype are genetically coupled in midbrain dopaminergic neurons.Scientific reports · 2018Article
- Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Postnatal development attunes olfactory bulb mitral cells to high-frequency signaling.Journal of neurophysiology · 2015Article
- Optimization of neuronal cultures from rat superior cervical ganglia for dual patch recording.Scientific reports · 2015Article
- Refining the Identity and Role of Kv4 Channels in Mouse Substantia Nigra Dopaminergic Neurons.eNeuroArticle
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons have complex electrophysiological properties, however, it is often difficult to determine which properties are the most relevant to neuronal function. By combining current-clamp measurements of electrophysiological properties with multi-variate analysis (hierarchical clustering, principal component analysis), we were able to characterize the postnatal development of substantia nigra dopaminergic neurons' electrical phenotype in an unbiased manner, such that subtle changes in phenotype could be analyzed. We show that the intrinsic electrical phenotype of these neurons follows a non-linear trajectory reaching maturity by postnatal day 14, with two developmental transitions occurring between postnatal days 3-5 and 9-11. This approach also predicted which parameters play a critical role in phenotypic variation, enabling us to determine (using pharmacology, dynamic-clamp) that changes in the leak, sodium and calcium-activated potassium currents are central to these two developmental transitions. This analysis enables an unbiased definition of neuronal type/phenotype that is applicable to a range of research questions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.