ArticleEnvironmental microbiology2015
Sioxanthin, a novel glycosylated carotenoid, reveals an unusual subclustered biosynthetic pathway.
Article in Environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- Taxonomic and biosynthetic diversity of the marine actinomyceteApplied and environmental microbiology · 2026Article
- Last Decade Insights in Exploiting Marine Microorganisms as Sources of New Bioactive Natural Products.Marine drugs · 2025Review
- Review
- Chromosome architecture as a determinant for biosynthetic diversity inMicrobial genomics · 2024Article
- Genome and Compound Analysis of Sioxanthin-Producing Marine Actinobacterium Micromonospora sp. nov. Strain SH-82 Isolated from Sponge Scopalina hapalia.Current microbiology · 2024Article
- The Endless World of Carotenoids-Structural, Chemical and Biological Aspects of Some Rare Carotenoids.International journal of molecular sciences · 2023Review
- Specialized Metabolite-Mediated Predation Defense in the Marine ActinobacteriumApplied and environmental microbiology · 2022Article
- Article
- Competition-based screening helps to secure the evolutionary stability of a defensive microbiome.BMC biology · 2021Article
- Influence of Cultivation Conditions on the Sioxanthin Content and Antioxidative Protection Effect of a Crude Extract from the Vegetative Mycelium ofMarine drugs · 2021Article
- High-level de novo biosynthesis of glycosylated zeaxanthin and astaxanthin in Escherichia coli.Bioresources and bioprocessing · 2021Article
- Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica.Microbial biotechnology · 2021Article
- Comparative Genomics and Metabolomics in the GenusmSystems · 2020Article
- Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products.Marine drugs · 2019Review
- Discovery of 16-Demethylrifamycins by Removing the Predominant Polyketide Biosynthesis Pathway inApplied and environmental microbiology · 2019Article
- Article
- Use of genome-scale models to get new insights into the marine actinomycete genus Salinispora.BMC systems biology · 2019Article
- Discovery and engineering of an endophyticJournal of biological engineering · 2019Article
- Draft Genome Sequence ofMicrobiology resource announcements · 2019Article
- Complete Genome of Micromonospora sp. Strain B006 Reveals Biosynthetic Potential of a Lake Michigan Actinomycete.Journal of natural products · 2018Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Members of the marine actinomycete genus Salinispora constitutively produce a characteristic orange pigment during vegetative growth. Contrary to the understanding of widespread carotenoid biosynthesis pathways in bacteria, Salinispora carotenoid biosynthesis genes are not confined to a single cluster. Instead, bioinformatic and genetic investigations confirm that four regions of the Salinispora tropica CNB-440 genome, consisting of two gene clusters and two independent genes, contribute to the in vivo production of a single carotenoid. This compound, namely (2'S)-1'-(β-D-glucopyranosyloxy)-3',4'-didehydro-1',2'-dihydro-φ,ψ-caroten-2'-ol, is novel and has been given the trivial name 'sioxanthin'. Sioxanthin is a C40 -carotenoid, glycosylated on one end of the molecule and containing an aryl moiety on the opposite end. Glycosylation is unusual among actinomycete carotenoids, and sioxanthin joins a rare group of carotenoids with polar and non-polar head groups. Gene sequence homology predicts that the sioxanthin biosynthetic pathway is present in all of the Salinispora as well as other members of the family Micromonosporaceae. Additionally, this study's investigations of clustering of carotenoid biosynthetic genes in heterotrophic bacteria show that a non-clustered genome arrangement is more common than previously suggested, with nearly half of the investigated genomes showing a non-clustered architecture.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.