SynthesisPloS one2014
Exposure to organochlorine pollutants and type 2 diabetes: a systematic review and meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02675101 (Nuts and Olestra for Persistent Organic Pollutant Reduction), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nuts and Olestra for Persistent Organic Pollutant Reduction (NO-POPs) Trial: A Pilot Investigation
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Association between DDT or its byproducts and T2DM: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Associations of per- and polyfluoroalkyl substances, polychlorinated biphenyls, organochlorine pesticides, and polybrominated diphenyl ethers with oxidative stress markers: A systematic review and meta-analysis.Environmental research · 2023Pooled it
- Diabetes mellitus and serum organochlorine pesticides mixtures in Mexican women.Environmental health : a global access science source · 2024Article
- Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures.Heliyon · 2024Review
- Serum concentration of polychlorinated biphenyls and the risk of type 2 diabetes: a 10-year follow-up historical cohort study.Scientific reports · 2024Article
- Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Santé cohort.Environmental health : a global access science source · 2022Observational
- Association of Organochlorine Pesticides With Genetic Markers of Endoplasmic Reticulum Stress in Type 2 Diabetes Mellitus: A Case-Control Study Among the North-Indian Population.Frontiers in endocrinology · 2022Article
- Associations of neonicotinoids with insulin and glucose homeostasis parameters in US adults: NHANES 2015-2016.Chemosphere · 2022Article
- Investigation of the association between pesticide exposure and the prevalence of type 2 diabetes in Shahedieh population in Yazd.Environmental science and pollution research international · 2021Article
- A Review on Occurrence of Pesticides in Environment and Current Technologies for Their Remediation and Management.Indian journal of microbiology · 2020Review
- Markers of acute toxicity of DDT exposure in pancreatic beta-cells determined by a proteomic approach.PloS one · 2020Article
- Upregulation of vitamin D-binding protein is associated with changes in insulin production in pancreatic beta-cells exposed to p,p'-DDT and p,p'-DDE.Scientific reports · 2019Article
- Examining environmental contaminant mixtures among adults with type 2 diabetes in the Cree First Nation communities of Eeyou Istchee, Canada.Scientific reports · 2019Article
- Constitutive androstane receptor mediates PCB-induced disruption of retinoid homeostasis.Toxicology and applied pharmacology · 2019Article
- Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors.Diabetologia · 2019Review
- Article
- Relationship between cumulative exposure to pesticides and sleep disorders among greenhouse vegetable farmers.BMC public health · 2019Article
- Silver nanoparticles inhibit beige fat function and promote adiposity.Molecular metabolism · 2019Article
- Organochlorine pesticides and polychlorinated biphenyls (PCBs) in early adulthood and blood lipids over a 23-year follow-up.Environmental toxicology and pharmacology · 2019Article
- Gut Microbiota Modulates Interactions Between Polychlorinated Biphenyls and Bile Acid Homeostasis.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThough exposure to organochlorine pollutants (OCPs) is considered a risk factor for type 2 diabetes (T2DM), epidemiological evidence for the association remains controversial. A systematic review and meta-analysis was applied to quantitatively evaluate the association between exposure to OCPs and incidence of T2DM and pool the inconsistent evidence. DESIGN AND
methodsPublications in English were searched in MEDLINE and WEB OF SCIENCE databases and related reference lists up to August 2013. Quantitative estimates and information regarding study characteristics were extracted from 23 original studies. Quality assessments of external validity, bias, exposure measurement and confounding were performed, and subgroup analyses were conducted to examine the heterogeneity sources.
resultsWe retrieved 23 eligible articles to conduct this meta-analysis. OR (odds ratio) or RR (risk ratio) estimates in each subgroup were discussed, and the strong associations were observed in PCB-153 (OR, 1.52; 95% CI, 1.19-1.94), PCBs (OR, 2.14; 95% CI, 1.53-2.99), and p,p'-DDE (OR, 1.33; 95% CI, 1.15-1.54) based on a random-effects model.
conclusionsThis meta-analysis provides quantitative evidence supporting the conclusion that exposure to organochlorine pollutants is associated with an increased risk of incidence of T2DM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.