Evidence map›Paper›PMID 25328905›Full record

ArticleAnnals of clinical and translational neurology2014

μ-Opioid activation in the midbrain during migraine allodynia - brief report II.

Thiago D Nascimento, Marcos F DosSantos, Sarah Lucas, Hendrik van Holsbeeck, Misty DeBoer, Eric Maslowski, Tiffany Love, Ilkka K Martikainen, Robert A Koeppe, Yolanda R Smith and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
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  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Physiopathology of Migraine: What Have We Learned from Functional Imaging?Current neurology and neuroscience reports · 2017
    Review
  10. Article
  11. Article
  12. Functional imaging and migraine: new connections?Current opinion in neurology · 2015
    Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Thiago D NascimentoHeadache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan.
Marcos F DosSantosHeadache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan.
Sarah LucasHeadache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan.
Hendrik van HolsbeeckHeadache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan.
Misty DeBoerHeadache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan.
Eric Maslowski3DLab, University of Michigan Ann Arbor, Michigan.
Tiffany LoveTranslational Neuroimaging Laboratory, Molecular and Behavioral Neuroscience Institute (MBNI), University of Michigan Ann Arbor, Michigan.
Ilkka K MartikainenHeadache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan ; Translational Neuroimaging Laboratory, Molecular and Behavioral Neuroscience Institute (MBNI), University of Michigan Ann Arbor, Michigan.
Robert A KoeppePET Physics Section, Division of Nuclear Medicine, Radiology Department, University of Michigan Ann Arbor, Michigan.
Yolanda R SmithDepartment of Obstetrics and Gynecology, University of Michigan Ann Arbor, Michigan.
Jon-Kar ZubietaTranslational Neuroimaging Laboratory, Molecular and Behavioral Neuroscience Institute (MBNI), University of Michigan Ann Arbor, Michigan.
Alexandre F DaSilvaHeadache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan ; Translational Neuroimaging Laboratory, Molecular and Behavioral Neuroscience Institute (MBNI), University of Michigan Ann Arbor, Michigan ; Michigan Center for Oral Health Research (MCOHR), School of Dentistry, University of Michigan Ann Arbor, Michigan.
University of Michigan–Ann Arbor · US

Funding

Structural and Molecular Neuroplasticity in Chronic Trigeminal PainK23NS062946 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DASILVA, ALEXANDRE · 2009 to 2013
$779k
NINDS NIH HHS K23 NS062946
6 · The paper itself

Abstract

We investigated in vivo the allodynic response of the central μ-opioid system during spontaneous migraine headaches, following a sustained pain threshold challenge on the trigeminal ophthalmic region. Six migraineurs were scanned during the ictal and interictal phases using positron emission tomography (PET) with the selective μ-opioid receptor (μOR) radiotracer [11C]carfentanil. Females were scanned during the mid-late follicular phase of two separate cycles. Patients showed ictal trigeminal allodynia during the thermal challenge that was concurrent and positively correlated with μOR activation in the midbrain, extending from red nucleus to ventrolateral periaqueductal gray matter. These findings demonstrate for the first time in vivo the high μOR activation in the migraineurs' brains in response to their allodynic experience.

Identifiers

PMID25328905
PMCPMC4184673
OpenAlexW2019061363

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.