ArticleJournal of research in pharmacy practice2014
Effects of Levothyroxine and thyroid stimulating hormone on bone loss in patients with primary hypothyroidism.
Article in Journal of research in pharmacy practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Effects of levothyroxine therapy on bone and mineral metabolism in hypothyroidism: a systematic review and meta-analysis.BMC endocrine disorders · 2025Pooled it
- Long-Term Selenium-Yeast Supplementation Does Not Affect Bone Turnover Markers: A Randomized Placebo-Controlled Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Trial
- Managing failed vital pulp therapies in mature permanent teeth in a retrospective cohort study, with success and survival rates of managing protocols.Scientific reports · 2024Article
- Association Between Periodontal Diseases and Hypothyroidism: A Case-Control Study.International journal of general medicine · 2024Article
- Pituitary crosstalk with bone, adipose tissue and brain.Nature reviews. Endocrinology · 2023Review
- The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepaticAmyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis · 2022Article
- Application and prospect of trabecular bone score in differentiated thyroid cancer patients receiving thyrotropin suppression therapy.Frontiers in endocrinology · 2022Review
- Restoration of euthyroidism in women with Hashimoto's thyroiditis changes bone microarchitecture but not estimated bone strength.Endocrine · 2021Article
- Health-related quality of life analysis in differentiated thyroid carcinoma patients after thyroidectomy.Scientific reports · 2020Article
- The Influence of Thyroid Pathology on Osteoporosis and Fracture Risk: A Review.Diagnostics (Basel, Switzerland) · 2020Review
- Actions of pituitary hormones beyond traditional targets.The Journal of endocrinology · 2018Review
- Therapeutic Effects of Laser on Partial Osteotomy in the Rat Model of Hypothyroidism.Journal of lasers in medical sciences · 2018Article
- The Combined Effects of Mesenchymal Stem Cell Conditioned Media and Low-Level Laser on Stereological and Biomechanical Parameter in Hypothyroidism Rat Model.Journal of lasers in medical sciences · 2018Article
- Original Research: Metabolic alterations from early life thyroxine replacement therapy in male Ames dwarf mice are transient.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- The Prevalence of Fragility Fractures in a Population of a Region of Southern Italy Affected by Thyroid Disorders.BioMed research international · 2016Observational
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrevious studies on bone mineral density (BMD) abnormalities associated with hypothyroidism are scarce and not conclusive. The effect of thyroid hormone therapy on BMD has shown mixed results. The aim of the present study was to determine the severities of osteoporosis in female patients with hypothyroidism in comparison to healthy women.
methodsThis cross-sectional descriptive study was performed on 150 women aged over 50 years. Totally, 100 patients with primary hypothyroidism and 50 healthy subjects were enrolled in this study and divided into three groups. Group A, which consisted the patients who had been recently diagnosed with primary hypothyroidism. The second group of patients diagnosed with primary hypothyroidism for at least 2 years and was treated with levothyroxine (Group B). The third group of healthy individuals was selected as a control group (Group C). Blood samples were taken for the measurements of thyroid stimulating hormone (TSH), and bone densitometry was performed to determine the BMD reported as T-score in order to measure the severity of osteoporosis. T-score of the lumbar vertebra (L2-L4) and femoral neck were measured with dual energy X-ray absorptiometry and were compared between the three groups. Data were analyzed by SPSS using regression analysis and Mann-Whitney, Kruskal-Wallis, or analysis of variances statistical tests. The statistical significance was set at a P < 0.05.
findingsThe average age of patients and baseline serum TSH levels in Group B was significantly different from the other two groups (P < 0.001). T-score of the lumbar spine (L2-L4) in Group B was significantly lower than the other groups (P = 0.01). The linear regression between serum TSH levels and BMD categories were not clearly associated. However, after removing the effect of the baseline TSH level in Group B, bone loss was significantly greater than the other two groups (P = 0.01).
conclusionAccording to the present study, it seems that the treatment of hypothyroidism with thyroid hormones reduces both serum levels of TSH and bone density. Hence, proper control of this risk factor can be an effective way in prevention of osteoporosis.
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