ArticleBioMed research international2014
Gender-dependent effect of GSTM1 genotype on childhood asthma associated with prenatal tobacco smoke exposure.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Association of glutathione S-transferase M1 and T1 genotypes with asthma: A meta-analysis.Medicine · 2020Pooled it
- Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review.Current allergy and asthma reports · 2018Pooled it
- Article
- The gut microbiota-NLRP3 inflammasome connection: current evidence and perspectives for non-communicable diseases.Molecular and cellular biochemistry · 2025Review
- Mother's smoking habits affects IL10 methylation but not asthma in Ecuadorian children.Molecular genetics & genomic medicine · 2024Article
- Interactions between glutathione S-transferase genes and household air pollution on asthma and lung function.Frontiers in molecular biosciences · 2022Review
- Gender-dependent association between exhaled nitric oxide and the CC16 38AA genotype in young school children.Immunity, inflammation and disease · 2020Article
- Influence of Second-Hand Smoke and Prenatal Tobacco Smoke Exposure on Biomarkers, Genetics and Physiological Processes in Children-An Overview in Research Insights of the Last Few Years.International journal of environmental research and public health · 2020Review
- Liver-Metabolizing Genes and Their Relationship to the Performance of Elite Spanish Male Endurance Athletes; a Prospective Transversal Study.Sports medicine - open · 2019Article
- Paternal Tobacco Smoke Correlated to Offspring Asthma and Prenatal Epigenetic Programming.Frontiers in genetics · 2019Article
- GSTM1 null genotype is a risk factor for laryngeal cancer.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It remains unclear whether the GSTM1 genotype interacts with tobacco smoke exposure (TSE) in asthma development. This study aimed to investigate the interactions among GSTM1 genotype, gender, and prenatal TSE with regard to childhood asthma development. In a longitudinal birth cohort in Taiwan, 756 newborns completed a 6-year follow-up, and 591 children with DNA samples available for GSTM1 genotyping were included in the study, and the interactive influences of gender-GSTM1 genotyping-prenatal TSE on childhood asthma development were analyzed. Among these 591 children, 138 (23.4%) had physician-diagnosed asthma at 6 years of age, and 347 (58.7%) were null-GSTM1. Prenatal TSE significantly increased the prevalence of childhood asthma in null-GSTM1 children relative to those with positive GSTM1. Further analysis showed that prenatal TSE significantly increased the risk of childhood asthma in girls with null-GSTM1. Furthermore, among the children without prenatal TSE, girls with null-GSTM1 had a significantly lower risk of developing childhood asthma and a lower total IgE level at 6 years of age than those with positive GSTM1. This study demonstrates that the GSTM1 null genotype presents a protective effect against asthma development in girls, but the risk of asthma development increases significantly under prenatal TSE.
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Registered trials
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