Trial reportBioMed research international2014
Exercise improves immune function, antidepressive response, and sleep quality in patients with chronic primary insomnia.
Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03163498 (Sleep, Mood and Physical Activity Level in Patients With Hypertension), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sleep, Mood and Physical Activity Level in Patients With Hypertension
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Global trends and hotspots in exercise therapy for insomnia research: bibliometric and visual analysis.Frontiers in neurology · 2025Pooled it
- Inflammatory cytokines and sleep parameters response to life style intervention in subjects with obese chronic insomnia syndrome.African health sciences · 2021Trial
- Aerobic versus resistance exercises on systemic inflammation and sleep parameters in obese subjects with chronic insomnia syndrome.African health sciences · 2021Trial
- Aerobic exercise modulates cytokine profile and sleep quality in elderly.African health sciences · 2019Trial
- Preventing Weight Gain Improves Sleep Quality Among Black Women: Results from a RCT.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2017Trial
- Effects of exercise and stress management training on nighttime blood pressure dipping in patients with coronary heart disease: A randomized, controlled trial.American heart journal · 2017Trial
- A Cross-Sectional Study Exploring a Mediation Model of Nature Exposure and Quality of Life: The Roles of Nature-Based and Overall Physical Activity.Behavioral sciences (Basel, Switzerland) · 2025Article
- Article
- Effects of Acute Aerobic ExerciseSleep science (Sao Paulo, Brazil) · 2025Article
- Unraveling the Complex Interplay Between Neuroinflammation and Depression: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Pet ownership, pet-related characteristics, and sleep quality among older adults in China: a nationwide cross-sectional study.Frontiers in veterinary science · 2025Article
- Structural and functional alterations in postmenopausal women with insomnia: an MRI study of Eight-Section Vajra Exercise intervention effects.Frontiers in neuroscience · 2025Article
- Psychiatric Characteristics, Symptoms of Insomnia and Depression, Emotion Regulation, and Social Activity among Swiss Medical Students.Journal of clinical medicine · 2024Article
- Sleep disturbances and psychological well-being among military medical doctors of the Swiss Armed Forces: study protocol, rationale and development of a cross-sectional and longitudinal interventional study.Frontiers in public health · 2024Article
- Genetic study of the causal effect of lipid profiles on insomnia risk: a Mendelian randomization trial.BMC medical genomics · 2023Article
- Effects of exercise timing and intensity on physiological circadian rhythm and sleep quality: a systematic review.Physical activity and nutrition · 2023Article
- Effects of 12 Weeks of Resistance Training on Body Composition, Muscle Hypertrophy and Function, Blood Lipid Level, and Hemorheological Properties in Middle-Aged Obese Women.Reviews in cardiovascular medicine · 2023Article
- Research on the relationship between physical activity, sleep quality, psychological resilience, and social adaptation among Chinese college students: A cross-sectional study.Frontiers in psychology · 2023Article
- The relationship between health belief and sleep quality of Chinese college students: The mediating role of physical activity and moderating effect of mobile phone addiction.Frontiers in public health · 2023Article
- Interactive effects of sleep and physical activity on depression among rural university students in China.Frontiers in psychology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the effects of moderate aerobic exercise training on sleep, depression, cortisol, and markers of immune function in patients with chronic primary insomnia. Twenty-one sedentary participants (16 women aged 44.7 ± 9 years) with chronic primary insomnia completed a 4-month intervention of moderate aerobic exercise. Compared with baseline, polysomnographic data showed improvements following exercise training. Also observed were reductions in depression symptoms and plasma cortisol. Immunologic assays revealed a significant increase in plasma apolipoprotein A (140.9 ± 22 to 151.2 ± 22 mg/dL) and decreases in CD4 (915.6 ± 361 to 789.6 ± 310 mm(3)) and CD8 (532.4 ± 259 to 435.7 ± 204 mm(3)). Decreases in cortisol were significantly correlated with increases in total sleep time (r = -0.51) and REM sleep (r = -0.52). In summary, long-term moderate aerobic exercise training improved sleep, reduced depression and cortisol, and promoted significant changes in immunologic variables.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.