Evidence map›Paper›PMID 25328765›Full record

ArticleJournal of gastric cancer2014

Expression levels of vascular endothelial growth factors a and C in patients with peptic ulcers and gastric cancer.

Shirin Taghizadeh, Mojtaba Sankian, Abolghasem Ajami, Mohsen Tehrani, Nasim Hafezi, Rajeeh Mohammadian, Touraj Farazmandfar, Vahid Hosseini, Ali Abbasi, Maryam Ajami

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In one paragraph

Article in Journal of gastric cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Shirin TaghizadehDepartment of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mojtaba SankianDepartment of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Abolghasem AjamiMolecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran. ; Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Mohsen TehraniDepartment of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Nasim HafeziDepartment of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Rajeeh MohammadianDepartment of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Touraj FarazmandfarFaculty of Advanced Medical Science Technology, Golestan University of Medical Sciences, Gorgan, Iran.
Vahid HosseiniInflammatory Diseases of Upper GI Tract Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Ali AbbasiDepartment of Pathology, Islamic Azad University, Sari Branch, Sari, Iran.
Maryam Ajami7 Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mazandaran University of Medical Sciences · IRMashhad University of Medical Sciences · IRGolestan University of Medical Sciences · IRIslamic Azad University Sari Branch · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeVascular endothelial growth factor (VEGF) is one of the most important growth factors for metastatic tumors. To clarify the role of VEGF-A and C in patients with peptic ulcer disease (PUD) or gastric cancer (GC), we evaluated the expression levels of these two molecules. We also analyzed the effect of Helicobacter pylori infection on VEGF-A and C expression levels. MATERIALS AND

methodsPATIENTS WITH DYSPEPSIA WHO NEEDED DIAGNOSTIC ENDOSCOPY WERE SELECTED AND DIVIDED INTO THREE GROUPS: non-ulcer dyspepsia (NUD), PUD, and GC, according to their endoscopic and histopathological results. Fifty-two patients with NUD, 50 with PUD, and 38 with GC were enrolled in this study. H. pylori infection was diagnosed by the rapid urease test. After RNA extraction and synthesis of cDNA, the expression levels of VEGF-A and C were determined by quantitative reverse transcriptase polymerase chain reaction.

resultsThe VEGF-C expression level in the PUD and GC groups was significantly higher than that in the NUD group. Moreover, the VEGF-A expression level in the PUD and GC groups was higher than in the NUD group, although the differences were not statistically significant. Significant positive correlations were also observed between the expression levels of these two molecules in the PUD and GC groups. In addition, the expression levels of these two molecules were higher in H. pylori positive patients with PUD or GC than in H. pylori negative patients of the same groups; however, these differences did not reach statistical significance.

conclusionsUp-regulation of VEGF-C expression during gastric mucosal inflammation may play a role in the development of peptic ulcers or GC.

Indexed as

Helicobacter pyloriPeptic ulcerStomach neoplasmsVascular endothelial growth factor-AVascular endothelial growth factor-C

Identifiers

PMID25328765
PMCPMC4199887
OpenAlexW1989202475

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.