ArticleBiomaterials science2014
Chemically diverse polymer microarrays and high throughput surface characterisation: a method for discovery of materials for stem cell culture†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4bm00054dClick here for additional data file.
Article in Biomaterials science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Advancements in theFrontiers in toxicology · 2025Review
- Modulation of Biomaterial-Associated Fibrosis by Means of Combined Physicochemical Material Properties.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Double-Orthogonal Gradient-Based High-Throughput Screening Platform for Studying Cell Response Toward Combined Physicochemical Biomaterial Properties.Small science · 2024Article
- Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors.Advanced materials (Deerfield Beach, Fla.) · 2022Article
- Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants.Molecules (Basel, Switzerland) · 2021Article
- High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology.Chemical reviews · 2021Review
- Discovery of a Novel Polymer for Xeno-Free, Long-Term Culture of Human Pluripotent Stem Cell Expansion.Advanced healthcare materials · 2021Article
- Harnessing biomolecules for bioinspired dental biomaterials.Journal of materials chemistry. B · 2020Review
- ToF-SIMS and Machine Learning for Single-Pixel Molecular Discrimination of an Acrylate Polymer Microarray.Analytical chemistry · 2020Article
- Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation.Advanced materials (Deerfield Beach, Fla.) · 2019Article
- Effect of surfactant onRSC advances · 2018Article
- Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Water contact angle is not a good predictor of biological responses to materials.Biointerphases · 2017Article
- Development of peptide-functionalized synthetic hydrogel microarrays for stem cell and tissue engineering applications.Acta biomaterialia · 2016Article
- Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion.Biomaterials science · 2016Article
- Polymer microarray technology for stem cell engineering.Acta biomaterialia · 2016Review
- Article
- Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.Advanced materials (Deerfield Beach, Fla.) · 2015Article
- Non-cell-adhesive substrates for printing of arrayed biomaterials.Advanced healthcare materials · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Materials discovery provides the opportunity to identify novel materials that are tailored to complex biological environments by using combinatorial mixing of monomers to form large libraries of polymers as micro arrays. The materials discovery approach is predicated on the use of the largest chemical diversity possible, yet previous studies into human pluripotent stem cell (hPSC) response to polymer microarrays have been limited to 20 or so different monomer identities in each study. Here we show that it is possible to print and assess cell adhesion of 141 different monomers in a microarray format. This provides access to the largest chemical space to date, allowing us to meet the regenerative medicine challenge to provide scalable synthetic culture ware. This study identifies new materials suitable for hPSC expansion that could not have been predicted from previous knowledge of cell-material interactions.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.