Evidence map›Paper›PMID 25328549›Full record

ArticleCancer nanotechnology2014

Cell localisation of gadolinium-based nanoparticles and related radiosensitising efficacy in glioblastoma cells.

Lenka Stefančíková, Erika Porcel, Pierre Eustache, Sha Li, Daniela Salado, Sergio Marco, Jean-Luc Guerquin-Kern, Matthieu Réfrégiers, Olivier Tillement, François Lux and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancer nanotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. Review
  3. New approaches to overcome radioresistance in glioblastoma: mechanisms, targets and role of innovative therapies, new particles and non-photon radiotherapy in 2024. A systematic review.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Review
  4. Article
  5. Targeting the organelle for radiosensitization in cancer radiotherapy.Asian journal of pharmaceutical sciences · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Radiobiological Implications of Nanoparticles Following Radiation Treatment.Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Lenka StefančíkováInstitut des Sciences Moléculaires d'Orsay (UMR 8214) Bât 351, Université Paris Sud, CNRS, 91405 Orsay Cedex, France.
Erika PorcelInstitut des Sciences Moléculaires d'Orsay (UMR 8214) Bât 351, Université Paris Sud, CNRS, 91405 Orsay Cedex, France.
Pierre EustacheInstitut des Sciences Moléculaires d'Orsay (UMR 8214) Bât 351, Université Paris Sud, CNRS, 91405 Orsay Cedex, France.
Sha LiInstitut des Sciences Moléculaires d'Orsay (UMR 8214) Bât 351, Université Paris Sud, CNRS, 91405 Orsay Cedex, France.
Daniela SaladoInstitut des Sciences Moléculaires d'Orsay (UMR 8214) Bât 351, Université Paris Sud, CNRS, 91405 Orsay Cedex, France.
Sergio MarcoInstitut Curie, centre de recherche, bat 112, Centre Universitaire, 91405 Orsay Cedex, France ; INSERM U759, bat 112, Centre Universitaire, 91405 Orsay Cedex, France.
Jean-Luc Guerquin-KernInstitut Curie, centre de recherche, bat 112, Centre Universitaire, 91405 Orsay Cedex, France ; INSERM U759, bat 112, Centre Universitaire, 91405 Orsay Cedex, France.
Matthieu RéfrégiersSynchrotron SOLEIL, BP48 Saint-Aubin, 91192 Gif-sur-Yvette, France.
Olivier TillementInstitut Lumière Matière, Université Claude Bernard Lyon 1, CNRS, 69622 Villeurbanne cedex, France.
François LuxInstitut Lumière Matière, Université Claude Bernard Lyon 1, CNRS, 69622 Villeurbanne cedex, France.
Sandrine LacombeInstitut des Sciences Moléculaires d'Orsay (UMR 8214) Bât 351, Université Paris Sud, CNRS, 91405 Orsay Cedex, France.
Institut des Sciences Moléculaires d'Orsay · FRInstitut Curie · FRUniversité Paris-Sud · FRCentre National de la Recherche Scientifique · FRInstitut Lumière Matière · FRSynchrotron soleil · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, the addition of nanoparticles (NPs) has been proposed as a new strategy to enhance the effect of radiotherapy particularly in the treatment of aggressive tumors such as glioblastoma. The physical processes involved in radiosensitisation by nanoparticles have been well studied although further understanding of its biological impact is still lacking, and this includes the localisation of these NPs in the target cells. Most studies were performed with NPs tagged with fluorescent markers. However, the presence of these markers can influence the NPs uptake and localisation. In this study, a set of methods was used to unambiguously and fully characterise the uptake of

Indexed as

Deep-UV synchrotron microscopyGadolinium- based nanoparticlesGlioblastomaLocalisationNanomedicineRadiosensitisationTheranosticTumor targeting

Identifiers

PMID25328549
PMCPMC4192560
OpenAlexW2168917541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.