Evidence map›Paper›PMID 25328407›Full record

ArticleOncoTargets and therapy2014

Prognostic value of preoperative inflammatory markers in Chinese patients with breast cancer.

Minya Yao, Yu Liu, Hailong Jin, Xiaojiao Liu, Kezhen Lv, Haiyan Wei, Chengyong Du, Shuqian Wang, Bajin Wei, Peifen Fu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  12. The prognostic value of neutrophil-to-lymphocyte ratio inAnnals of translational medicine · 2023
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Minya YaoDepartment of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Yu LiuDepartment of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Hailong JinGastrointestinal Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Xiaojiao LiuDepartment of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Kezhen LvDepartment of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Haiyan WeiDepartment of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Chengyong DuDepartment of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Shuqian WangDepartment of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Bajin WeiDepartment of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Peifen FuDepartment of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer-associated inflammation is a key determinant of disease progression and survival in most cancers. The aim of our study was to assess the predictive value of preoperative inflammatory markers, such as the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, red cell distribution width (RDW), and mean platelet volume, for survival in breast cancer patients. In total, 608 breast cancer patients operated on between January 2009 and December 2011 were included in this observational study. The association between preoperative inflammatory markers and survival outcomes was analyzed. Patients with high NLR (>2.57) or high RDW (>13.45%) showed a significantly lower overall survival rate than those with lower NLR (≤2.57) or lower RDW (≤13.45%). NLR and RDW, along with node stage and molecular subtypes, were independent prognostic factors. There was a significant survival difference according to NLR in the luminal A and triple-negative subtypes (93.3% versus 99.3%, P=0.001; 68.8% versus 95.1%, P=0.000, respectively). The triple-negative subtype was the only subtype in which higher RDW patients showed significantly poor prognosis (81.3% versus 95.5%, P=0.025). Pre-operation NLR and RDW is a convenient, easily measured prognostic indicator for patients with breast cancer, especially in patients with the triple-negative subtype.

Indexed as

neutrophil-to-lymphocyte ratioNLRoverall survivalRDWred cell distribution width

Identifiers

PMID25328407
PMCPMC4196795

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.