ArticleActa anaesthesiologica Scandinavica2015
Osteopontin is associated with inflammation and mortality in a mouse model of polymicrobial sepsis.
Article in Acta anaesthesiologica Scandinavica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- ICOSL: more than a trigger of ICOS function.Cell communication and signaling : CCS · 2025Review
- Osteopontin Depletion in Nonhematopoietic Cells Improves Outcomes in Septic Mice by Enhancing Antimicrobial Peptide Production.The Journal of infectious diseases · 2024Article
- Osteopontin and Clinical Outcomes in Hemodialysis Patients.Biomedicines · 2024Article
- ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis.Frontiers in immunology · 2022Article
- A long journey for acute kidney injury biomarkers.Renal failure · 2020Review
- Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis Through miR-17-5p Downregulating TLR4.Inflammation · 2019Article
- The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock.Cells · 2019Observational
- Osteopontin Expression in Cardiomyocytes Is Increased in Pediatric Patients With Sepsis or Pneumonia.Frontiers in physiology · 2018Article
- Persistently elevated osteopontin serum levels predict mortality in critically ill patients.Critical care (London, England) · 2015Article
- Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury.Critical care (London, England) · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOsteopontin (OPN) is a multifunctional glycoprotein with pro-inflammatory properties. In severe sepsis, levels of plasma OPN are significantly higher in non-survivors than in survivors. We hypothesized that OPN results in greater inflammation and worse outcome through modulation of endogenous glucocorticoid production in sepsis. METHODS AND
resultsSepsis was induced by cecal ligation and puncture (CLP) in wild type (WT) and OPN gene knockout (OPN(-/-) ) mice. In response to sepsis, the OPN(-/-) mice had lower levels of plasma cytokines and chemokines than the WT mice. The levels of corticosterone in plasma were similar between WT and OPN(-/-) sham animals but they increased 24 h after CLP induction in the WT mice, but not in the OPN(-/-) mice. The mortality rate was lower in the OPN(-/-) mice than in the WT mice.
conclusionOPN is associated with greater inflammatory response and increased mortality, despite the higher corticosterone levels in plasma. Corticosterone production is not impaired in the absence of OPN.
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