ArticleActa pharmacologica Sinica2014
Serum osteocalcin levels are inversely associated with plasma glucose and body mass index in healthy Chinese women.
Article in Acta pharmacologica Sinica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Association between serum osteocalcin and body mass index: a systematic review and meta-analysis.Endocrine · 2017Pooled it
- Age- and sex-specific differences in the association of serum osteocalcin and cardiometabolic risk factors in type 2 diabetes.Diabetology & metabolic syndrome · 2023Article
- Circulating osteocalcin is associated with time in range and other metrics assessed by continuous glucose monitoring in type 2 diabetes.Diabetology & metabolic syndrome · 2022Article
- The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus.Endocrine · 2022Article
- Article
- Increased Plasma Osteocalcin, Oral Disease, and Altered Mandibular Bone Density in Postmenopausal Women.International journal of dentistry · 2019Article
- Nontraditional Cardiovascular Biomarkers and Risk Factors: Rationale and Future Perspectives.Biomolecules · 2018Review
- Association of bone turnover markers with glucose metabolism in Chinese population.Acta pharmacologica Sinica · 2017Article
- Association between serum osteocalcin and glucose/lipid metabolism in Chinese Han and Uygur populations with type 2 diabetes mellitus in Xinjiang: two cross-sectional studies.Lipids in health and disease · 2017Article
- An overview of osteocalcin progress.Journal of bone and mineral metabolism · 2016Review
- Inverse relationship between serum osteocalcin levels and nonalcoholic fatty liver disease in postmenopausal Chinese women with normal blood glucose levels.Acta pharmacologica Sinica · 2015Article
- Searching for additional endocrine functions of the skeleton: genetic approaches and implications for therapeutics.Expert review of endocrinology & metabolismArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
aimOsteocalcin, a biochemical marker of bone formation, has been suggested to be involved in the regulation of energy metabolism. The aim of this study was to investigate the possible association between serum osteocalcin and markers of glucose and lipid metabolism in a large sample of healthy Chinese women.
methodsA total of 2032 healthy Chinese women in Shanghai, aged 20-94 (including 1396 discovery-study subjects and 636 postmenopausal women for a reduplication analysis) were recruited. Their serum osteocalcin, calcium and the relevant measurements were analyzed. A Spearman correlation analysis was performed between osteocalcin and the other markers of energy metabolism including triglyceride, total cholesterol, fasting plasma glucose (FPG), serum insulin, body mass index and homeostasis model assessment-insulin resistance. Separate multiple regression analyses were performed with data from the discovery and reduplication subjects to determine whether serum osteocalcin concentration was an independent predictor of the glucose or lipid metabolism markers.
resultsFor the discovery-study subjects, serum osteocalcin was found to be negatively associated with weight (r=-0.08, P=0.002), BMI (-0.13, P<0.001) and FPG (r=-0.13, P=0.001). Similar results were also found in the reduplication subjects (weight: r=-0.19, P=0.016; BMI: r=-0.23, P=0.003; FPG: r=-0.28, P<0.001). In the multiple regression analysis, serum osteocalcin was revealed as a potential independent predictor for FPG (β=-0.07 and -0.210 for discovery and reduplication, respectively, P<0.01) and BMI (β=-0.127 and -0.299 for discovery and reduplication, respectively, P<0.01).
conclusionSerum osteocalcin is negatively associated with weight BMI and FPG in healthy Chinese women. Therefore, osteocalcin might contribute to obesity and diabetes.
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