ArticleNature communications2014
The meta-epigenomic structure of purified human stem cell populations is defined at cis-regulatory sequences.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Targeting telomerase with MST-312 leads to downregulation of CCND1, MDM2, MYC, and HSP90AA1 and induce apoptosis in Jurkat cell line.Medical oncology (Northwood, London, England) · 2024Article
- Epigenomic and epigenetic investigations of food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Review
- Article
- Epigenetic and Transcriptomic Programming of HSC Quiescence Signaling in Large for Gestational Age Neonates.International journal of molecular sciences · 2022Article
- CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer.Nature communications · 2021Article
- Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements andHaematologica · 2019Article
- Characterization of Blood Surrogate Immune-Methylation Biomarkers for Immune Cell Infiltration in Chronic Inflammaging Disorders.Frontiers in genetics · 2019Article
- Genetic variants influence on the placenta regulatory landscape.PLoS genetics · 2018Article
- Epigenetics and developmental origins of diabetes: correlation or causation?American journal of physiology. Endocrinology and metabolism · 2018Review
- Enhancer DNA methylation in acute myeloid leukemia and myelodysplastic syndromes.Cellular and molecular life sciences : CMLS · 2018Review
- Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants.Molecular metabolism · 2017Article
- DNA methylation signatures of chronic alcohol dependence in purified CD3Scientific reports · 2017Article
- Associating cellular epigenetic models with human phenotypes.Nature reviews. Genetics · 2017Review
- A pre-neoplastic epigenetic field defect in HCV-infected liver at transcription factor binding sites and polycomb targets.Oncogene · 2017Article
- Population Epigenetics.Current opinion in systems biology · 2017Article
- Article
- Epigenetic Alterations Affecting Transcription Factors and Signaling Pathways in Stromal Cells of Endometriosis.PloS one · 2017Article
- DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation.Cell stem cell · 2016Article
- Advanced aging phenotype is revealed by epigenetic modifications in rat liver after in utero malnutrition.Aging cell · 2016Article
- Novel regional age-associated DNA methylation changes within human common disease-associated loci.Genome biology · 2016Article
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7 authors.
Funding
Abstract
The mechanism and significance of epigenetic variability in the same cell type between healthy individuals are not clear. Here we purify human CD34+ haematopoietic stem and progenitor cells (HSPCs) from different individuals and find that there is increased variability of DNA methylation at loci with properties of promoters and enhancers. The variability is especially enriched at candidate enhancers near genes transitioning between silent and expressed states, and encoding proteins with leukocyte differentiation properties. Our findings of increased variability at loci with intermediate DNA methylation values, at candidate 'poised' enhancers and at genes involved in HSPC lineage commitment suggest that CD34+ cell subtype heterogeneity between individuals is a major mechanism for the variability observed. Epigenomic studies performed on cell populations, even when purified, are testing collections of epigenomes, or meta-epigenomes. Our findings show that meta-epigenomic approaches to data analysis can provide insights into cell subpopulation structure.
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