Evidence map›Paper›PMID 25326793›Full record

SynthesisMedical science monitor : international medical journal of experimental and clinical research2014

Association between miR34b/c polymorphism rs4938723 and cancer risk: a meta-analysis of 11 studies including 6169 cases and 6337 controls.

Xinjing Wang, Xiongxiong Lu, Yuan Fang, Hao Chen, Xiaxing Deng, Chenghong Peng, Hongwei Li, Baiyong Shen

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Association Between ESR1 PvuII, XbaI, and P325P Polymorphisms and Breast Cancer Susceptibility: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Pooled it
  3. Association between Genetic Polymorphisms in DEFB1 and Susceptibility to Digestive Diseases.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Pri-miR-34b/c rs4938723 polymorphism increased the risk of prostate cancer.Cancer biomarkers : section A of Disease markers · 2017
    Article
  11. Article
  12. Combined analysis of pri-miR-34b/c rs4938723 and TP53 Arg72Pro with cervical cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  13. Plasma miR-15b-5p, miR-338-5p, and miR-764 as Biomarkers for Hepatocellular Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Article
  14. MiR-506 Over-Expression Inhibits Proliferation and Metastasis of Breast Cancer Cells.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xinjing WangDepartment of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
Xiongxiong LuDepartment of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
Yuan FangDepartment of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
Hao ChenDepartment of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
Xiaxing DengDepartment of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
Chenghong PengDepartment of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
Hongwei LiDepartment of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
Baiyong ShenDepartment of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
Ruijin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe functional polymorphism rs4938723 in the promoter region of pri-miR-34b/c is potentially associated with susceptibility to several cancers, including hepatocellular carcinoma, colorectal cancer, and breast cancer. Here we conducted a comprehensive meta-analysis to investigate the association between rs4938723 and cancer risk. MATERIAL AND

methodsEligible studies extracted from the databases of PubMed, Web of Science, and Cochrane Library were evaluated. Statistical analysis was performed using Revman 5.2 and STATA 12.0 software.

resultsBy characterizing the extracted data, a total of 11 studies reported in 10 publications including 6169 cases and 6337 controls were selected for further analysis. Our results revealed a significant association between the rs4938723 polymorphism and cancer risk in the codominant model (TC vs. TT: OR=1.10, 95% CI=1.02-1.19, P=0.009) but not in other genetic models. In the stratified analysis of different cancer types, a significant association was found in nasopharyngeal cancer, osteosarcoma, and renal cell cancer. Furthermore, stratified analysis of ethnicity indicated that a highly significant association was shown in the Asian population in a codominant model (TC vs. TT: OR=1.13, 95% CI=1.03-1.24, P=0.007) when compared with African-Americans and Caucasians.

conclusionsOverall, the current study suggests that the miR-34b/c rs4938723 polymorphism may be associated with the risk of cancers, including nasopharyngeal cancer, osteosarcoma, and renal cell cancer, and to some extent this polymorphism is closely related to cancer susceptibility in Asians.

Indexed as

Polymorphism, GeneticCase-Control StudiesHumansMicroRNAsNeoplasmsMicroRNAsMIRN34 microRNA, human

Identifiers

PMID25326793
PMCPMC4213004
OpenAlexW2066487707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.