Trial reportJACC. Cardiovascular interventions2014
Intravascular ultrasound guidance to minimize the use of iodine contrast in percutaneous coronary intervention: the MOZART (Minimizing cOntrast utiliZation With IVUS Guidance in coRonary angioplasTy) randomized controlled trial.
Trial report in JACC. Cardiovascular interventions, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 75 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Minimizing cOntrast utiliZAtion With IVUS Guidance in coRonary angioplasTy: The MOZART Study
Renal Insufficiency Following Contrast Media Administration Trial IV: Contrast Media Volume Control for Limiting Contrast-Induced Acute Kidney in Acute Coronary Syndrome.
IVUS Based Ultra-low Volume Contrast Media PCI to Reduce Contrast Induced Nephrology in Patient With Chronic Kidney disease-a Multi-center, Open Label, Randomized Trial (IVUS-CKD)
Who cites it
75 citing papers in PubMed, 6 syntheses or guidelines pooled it, 196 citations in OpenAlex.
- Ultra-Low Contrast versus Conventional Percutaneous Coronary Intervention for Patients with Baseline Renal Impairment: A Systematic Review and Meta-Analysis of Clinical Outcomes.Arquivos brasileiros de cardiologia · 2026Pooled it
- Intravascular imaging-guided versus angiography-guided percutaneous coronary intervention: a systematic review and bayesian network meta-analysis of randomized controlled trials.BMC cardiovascular disorders · 2024Pooled it
- Intravascular Ultrasound Use in Peripheral Arterial and Deep Venous Interventions: Multidisciplinary Expert Opinion From SCAI/AVF/AVLS/SIR/SVM/SVS.Journal of vascular and interventional radiology : JVIR · 2024Guideline
- Intravascular imaging guided versus coronary angiography guided percutaneous coronary intervention: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2023Pooled it
- Shortage of iodinated contrast media: Status and possible chances - A systematic review.European journal of radiology · 2023Pooled it
- Clinical Outcomes Following Hemodynamic Parameter or Intravascular Imaging-Guided Percutaneous Coronary Intervention in the Era of Drug-Eluting Stents: An Updated Systematic Review and Bayesian Network Meta-Analysis of 28 Randomized Trials and 11,860 Patients.Frontiers in cardiovascular medicine · 2022Pooled it
- Intravascular Imaging in Patients With Complex Coronary Lesions and Chronic Kidney Disease.JAMA network open · 2023Trial
- Ultra-low CONtraSt PCI vs conVEntional PCI in patients of ACS with increased risk of CI-AKI (CONSaVE-AKI).Indian heart journalTrial
- Intravascular Imaging to Predict the Coronary No-Reflow and Slow-Flow Phenomena: Advances and Perspectives.Reviews in cardiovascular medicine · 2026Review
- Multimodality Approach to Coronary Ischemic Testing in Pediatric Patients: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2026Review
- Time To Inject Some Contrast into the Nephrotoxicity Debate.Kidney360 · 2026Article
- Live IVUS-guided wiring in percutaneous coronary intervention: a case report.European heart journal. Case reports · 2026Article
- TAP (T and Small Protrusion) and Culotte Stenting Techniques Versus a Reverse Crush in Case of Bailout of Provisional Stenting.Journal of cardiovascular development and disease · 2026Article
- Comparative effectiveness and outcomes of physiology- and imaging-guided PCI: an evidence synthesis and network meta-analysis of FFR, iFR, OCT, and IVUS.Frontiers in cardiovascular medicine · 2026Review
- From Coronary Artery to Kidney: Redefining the Goals of Intracoronary Imaging-Optimized Percutaneous Coronary Intervention.Arquivos brasileiros de cardiologia · 2026Article
- Heroes of Zero: Clinical Pearls on Performing Zero-Contrast Percutaneous Coronary Intervention.JACC. Case reports · 2025Article
- From Echo to Coronary Angiography: Optimizing Ischemia Evaluation Through Multimodal Imaging.Medicina (Kaunas, Lithuania) · 2025Review
- Expanding Applications of Three-Dimensional Cardiac Mapping Systems: A Review.Journal of clinical medicine · 2025Review
- Left-Digit Bias in Serum Creatinine Levels and Contrast Administration: A Nationwide Cohort Study Using a Japanese Percutaneous Coronary Intervention Registry.Journal of the American Heart Association · 2025Article
- In-Hospital Outcomes and Temporal Trends of Surgical Versus Intravascular Ultrasound-Guided Endovascular Interventions for Femoropopliteal Disease.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 4 countries.
Funding
Abstract
objectivesThe aim of this study was to evaluate the impact of intravascular ultrasound (IVUS) guidance on the final volume of contrast agent used in patients undergoing percutaneous coronary intervention (PCI).
backgroundTo date, few approaches have been described to reduce the final dose of contrast agent in PCIs. We hypothesized that IVUS might serve as an alternative imaging tool to angiography in many steps during PCI, thereby reducing the use of iodine contrast.
methodsA total of 83 patients were randomized to angiography-guided PCI or IVUS-guided PCI; both groups were treated according to a pre-defined meticulous procedural strategy. The primary endpoint was the total volume contrast agent used during PCI. Patients were followed clinically for an average of 4 months.
resultsThe median total volume of contrast was 64.5 ml (interquartile range [IQR]: 42.8 to 97.0 ml; minimum, 19 ml; maximum, 170 ml) in the angiography-guided group versus 20.0 ml (IQR: 12.5 to 30.0 ml; minimum, 3 ml; maximum, 54 ml) in the IVUS-guided group (p < 0.001). Similarly, the median volume of contrast/creatinine clearance ratio was significantly lower among patients treated with IVUS-guided PCI (1.0 [IQR: 0.6 to 1.9] vs. 0.4 [IQR: 0.2 to 0.6, respectively; p < 0.001). In-hospital and 4-month outcomes were not different between patients randomized to angiography-guided and IVUS-guided PCI.
conclusionsThoughtful and extensive use of IVUS as the primary imaging tool to guide PCI is safe and markedly reduces the volume of iodine contrast compared with angiography-alone guidance. The use of IVUS should be considered for patients at high risk of contrast-induced acute kidney injury or volume overload undergoing coronary angioplasty. (Minimizing cOntrast utiliZation With IVUS Guidance in coRonary angioplasTy [MOZART]; NCT01947335).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.