ArticleVirology journal2014
Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis in Hong Kong.
Article in Virology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- Detection and Genetic Characteristics of Cosavirus and Salivirus in the Wastewater, China.Food and environmental virology · 2025Article
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- Comparative analysis of reverse-transcription-polymerase chain reaction for Aichivirus detection.Food science and biotechnology · 2024Article
- Detection of parechovirus A in respiratory, gastrointestinal, and neurological clinical samples of pediatric patients from Panama (2014-2015).Virology journal · 2023Article
- Metagenomic Surveillance of Viral Gastroenteritis in a Public Health Setting.Microbiology spectrum · 2023Article
- A Comparative Study of Acute Gastroenteritis Symptoms in Single- versus Multiple-Virus Infections.International journal of molecular sciences · 2023Article
- Composition of Eukaryotic Viruses and Bacteriophages in Individuals with Acute Gastroenteritis.Viruses · 2021Article
- Multiple Types of Novel Enteric Bopiviruses (Viruses · 2021Article
- Molecular Detection of Human Salivirus in Italy Through Monitoring of Urban Sewages.Food and environmental virology · 2020Article
- Review
- Development of Rapid and Specific Detection for the HumanIndian journal of microbiology · 2019Article
- Aichi Virus Induces Antiviral Host Defense in Primary Murine Intestinal Epithelial Cells.Viruses · 2019Article
- Occurrence of Salivirus in Sewage and River Water Samples in Karaj, Iran.Food and environmental virology · 2019Article
- The First Molecular Detection of Aichi Virus 1 in Raw Sewage and Mussels Collected in South Africa.Food and environmental virology · 2019Article
- Advances in Diagnostic Approaches for Viral Etiologies of Diarrhea: From the Lab to the Field.Frontiers in microbiology · 2019Review
- Review
- Severe Parechovirus 3 Infections in Young Infants-Kansas and Missouri, 2014.Journal of the Pediatric Infectious Diseases Society · 2018Article
- Human Parechovirus: an Increasingly Recognized Cause of Sepsis-Like Illness in Young Infants.Clinical microbiology reviews · 2018Review
- Clinical features and seasonality of parechovirus infection in an Asian subtropical city, Hong Kong.PloS one · 2017Article
- Equine rhinitis B viruses in horse fecal samples from the Middle East.Virology journal · 2016Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging human picornaviruses, including human parechovirus (HPeV), Aichi virus (AiV) and salivirus (SalV) were found to be associated with gastroenteritis, but their roles in enteric infections are not fully understood. In addition, no report on the circulation of these viruses in Hong Kong is available. The objective of this study was to investigate the prevalence and genetic diversity of HPeV, AiV and SalV in fecal samples from hospitalized children with gastroenteritis in Hong Kong.
methodsFecal samples from hospitalized children with gastroenteritis were subject to detection of HPeV, AiV and SalV by RT-PCR using consensus primers targeted to their 5'UTRs. Positive samples were subject to capsid and/or 3CD region analysis for genotype determination. The epidemiology of HPeV, AiV and SalV infections was analyzed.
resultsAmong 1,708 fecal samples subjected to RT-PCR using primers targeted to 5'UTR of HPeV, AiV and SalV, viruses were detected in 55 samples, with 50 positive for HPeV only, 3 positive for AiV only, 1 positive for both HPeV and AiV, and 1 positive for both HPeV and SalV. Phylogenetic analysis of the partial VP1 gene of the 33 HPeV strains revealed the presence of genotypes of HPeV- 1, 3, 4, 5, 7, 10, among which HPeV-1 was the predominant genotype circulating in our population. The peak activity of HPeV infection was in fall. Of the 3 children with AiV infection, the 3 AiV strains were found to belong to genotype A based on the phylogenetic analysis of their partial VP1 and 3CD regions. The genotype of a SalV strain detected in this study could not be determined. Co-detection of different pathogens was observed in 24 samples (43.6%) of 55 fecal samples positive for HPeV, AiV and SalV.
conclusionsHPeV, AiV and SalV were detected in fecal samples of hospitalized children with gastroenteritis in Hong Kong, with the former having the highest prevalence. HPeV-1 was the predominant genotype among HPeVs, while genotype A was the predominant genotype among AiVs in this study.
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