ArticleAmerican journal of physiology. Lung cellular and molecular physiology2015
HER2 activation results in β-catenin-dependent changes in pulmonary epithelial permeability.
Article in American journal of physiology. Lung cellular and molecular physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Air pollution-induced airway epithelial barrier dysfunction in COPD: a narrative review of mechanisms and therapeutic implications.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Bufei Yishen formula protects the airway epithelial barrier and ameliorates COPD by enhancing autophagy through the Sirt1/AMPK/Foxo3 signaling pathway.Chinese medicine · 2024Article
- Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Nuclear translocation of β-catenin induced by E-cadherin endocytosis causes recurrent erosion of diabetic cornea.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Role of mTOR As an Essential Kinase in SCLC.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2020Article
- Article
- Interleukin-6 is required for Neuregulin-1 induced HER2 signaling in lung epithelium.Biochemical and biophysical research communications · 2019Article
- Penfluridol overcomes paclitaxel resistance in metastatic breast cancer.Scientific reports · 2019Article
- Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence.Cancer medicine · 2019Article
- HER2 Signaling Implicated in Regulating Alveolar Epithelial Permeability with Cyclic Stretch.International journal of molecular sciences · 2019Article
- Macrophages as an Emerging Source of Wnt Ligands: Relevance in Mucosal Integrity.Frontiers in immunology · 2019Review
- Cigarette Smoke Induces Human Epidermal Receptor 2-Dependent Changes in Epithelial Permeability.American journal of respiratory cell and molecular biology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The receptor tyrosine kinase human epidermal growth factor receptor-2 (HER2) is known to regulate pulmonary epithelial barrier function; however, the mechanisms behind this effect remain unidentified. We hypothesized that HER2 signaling alters the epithelial barrier through an interaction with the adherens junction (AJ) protein β-catenin, leading to dissolution of the AJ. In quiescent pulmonary epithelial cells, HER2 and β-catenin colocalized along the lateral intercellular junction. HER2 activation by the ligand neuregulin-1 was associated with tyrosine phosphorylation of β-catenin, dissociation of β-catenin from E-cadherin, and decreased E-cadherin-mediated cell adhesion. All effects were blocked with the HER2 inhibitor lapatinib. β-Catenin knockdown using shRNA significantly attenuated neuregulin-1-induced decreases in pulmonary epithelial resistance in vitro. Our data indicate that HER2 interacts with β-catenin, leading to dissolution of the AJ, decreased cell-cell adhesion, and disruption of the pulmonary epithelial barrier.
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