Evidence map›Paper›PMID 25326546›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2014

Thymic stromal lymphopoietin and cancer.

Emma Lo Kuan, Steven F Ziegler

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 50 citations in OpenAlex.

  1. International journal of molecular sciences · 2025
    Article
  2. TSLP: contrasting roles in cancer.Frontiers in immunology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Dendritic Cell-Mediated Th2 Immunity and Immune Disorders.International journal of molecular sciences · 2019
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. IL-2 and Beyond in Cancer Immunotherapy.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2018
    Review
  19. Thymic stromal lymphopoietin drives the development of IL-13Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution.

Emma Lo KuanImmunology Program, Benaroya Research Institute, Seattle, WA 98101.
Steven F ZieglerImmunology Program, Benaroya Research Institute, Seattle, WA 98101 sziegler@benaroyaresearch.org.
Benaroya Research Institute

Funding

Thymic Stromal Lymphopoietin (TSLP) and Lung Inflammation and ImmP01HL098067 · NHLBI · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2010 to 2014
$13.5M
TSLP and the Pathophysiology of AsthmaR01AI068731 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2006 to 2016
$4.5M
Control of tumor growth and metastasis by the cytokine TSLPR01CA182783 · NCI · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2014 to 2018
$2.1M
TSLP and Contact HypersensitivityR01AR056113 · NIAMS · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2008 to 2012
$2.0M
NCI NIH HHS R01 CA182783NHLBI NIH HHS P01 HL098067NIAID NIH HHS R01 AI068731NIAMS NIH HHS R01 AR056113
6 · The paper itself

Abstract

Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging effects on both hematopoietic and nonhematopoietic cell lineages. These include dendritic cells, basophils, mast cells, B cells, epithelial cells, and CD4(+), CD8(+), and NK T cells. Although TSLP's role in the promotion of Th2 responses has been studied extensively in the context of lung- and skin-specific allergic disorders, it is becoming increasingly clear that TSLP may impact multiple disease states within multiple organ systems. This review highlights recent advances in the understanding of the surprising role of TSLP in the control of a variety of cancers, both solid tumors and leukemia, in which the TSLP/TSLP receptor axis was shown to be an important regulator.

Indexed as

AnimalsCytokinesGene Expression Regulation, NeoplasticHumansNeoplasmsProtein BindingReceptors, CytokineSignal TransductionThymic Stromal LymphopoietinTumor MicroenvironmentCytokinesReceptors, CytokineThymic Stromal Lymphopoietin

Identifiers

PMID25326546
PMCPMC4203400
OpenAlexW1779361648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.