ArticleStem cell reviews and reports2015
Bone Marrow Mesenchymal Stromal Cells Induce Proliferative, Cytokinic and Molecular Changes During the T Cell Response: The Importance of the IL-10/CD210 Axis.
Article in Stem cell reviews and reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- IL-10RA governor the expression of IDO in the instruction of lymphocyte immunity.British journal of cancer · 2025Article
- Stromal vascular fraction in the treatment of myositis.Cell death discovery · 2023Review
- Clinical progress in MSC-based therapies for the management of severe COVID-19.Cytokine & growth factor reviews · 2022Review
- Enforced mesenchymal stem cell tissue colonization counteracts immunopathology.NPJ Regenerative medicine · 2022Article
- Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review.Genes · 2022Review
- TNF-α and IFN-γ Participate in Improving the Immunoregulatory Capacity of Mesenchymal Stem/Stromal Cells: Importance of Cell-Cell Contact and Extracellular Vesicles.International journal of molecular sciences · 2021Review
- Latest advances to enhance the therapeutic potential of mesenchymal stromal cells for the treatment of immune-mediated diseases.Drug delivery and translational research · 2021Article
- Novel insights for improving the therapeutic safety and efficiency of mesenchymal stromal cells.World journal of stem cells · 2020Review
- Degenerative osteoarthritis a reversible chronic disease.Regenerative therapy · 2020Review
- Stem Cells in Veterinary Medicine-Current State and Treatment Options.Frontiers in veterinary science · 2020Review
- Mesenchymal Stromal Cell Immunology for Efficient and Safe Treatment of Osteoarthritis.Frontiers in cell and developmental biology · 2020Review
- Immunomodulatory properties of dental tissue-derived mesenchymal stem cells: Implication in disease and tissue regeneration.World journal of stem cells · 2019Review
- Aldehyde dehydrogenase activity of Wharton jelly mesenchymal stromal cells: isolation and characterization.Cytotechnology · 2019Article
- Empowering the immune fate of bone marrow mesenchymal stromal cells: gene and protein changes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Article
- Role of Regulatory Immune Cells and Molecules in Autoimmune Bullous Dermatoses.Frontiers in immunology · 2019Review
- Interleukin 17 (IL-17)-Induced Mesenchymal Stem Cells Prolong the Survival of Allogeneic Skin Grafts.Annals of transplantation · 2018Article
- Article
- Mesenchymal Stem Cells in Primary Sjögren's Syndrome: Prospective and Challenges.Stem cells international · 2018Review
- Immunomodulation by Mesenchymal Stromal Cells and Their Clinical Applications.Journal of stem cell and regenerative biology · 2017Article
- Immunomodulatory effects of mesenchymal stromal cells-derived exosome.Immunologic research · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBone marrow mesenchymal stromal cells (BM-MSCs) display immunomodulatory features, representing a promising tool for cell-based therapies. However, the mechanisms used by MSCs to regulate T cell fate remain unclear.
aimsWe investigated the potential of BM-MSCs to modulate T cell activation, proliferation, cytokine secretion and immunophenotype. MATERIALS AND
methodsT cells were co-cultured with BM-MSCs to assess their immunomodulatory impact. T cell characterization was performed using cell tracing, ELISA, intracellular and surface staining, flow cytometry analysis and qPCR.
resultsThe activation and proliferation of T cells were downregulated during coculture with BM-MSCs. We also observed that BM-MSCs upregulated IL-10 secretion as well as the expression of its receptor CD210 on T cells, thus creating a loop favoring the expansion of IL-10-producing T cells. IL-10 neutralization restored T cell proliferation, demonstrating that IL-10 is functionally relevant during immunomodulation. Moreover, BM-MSCs differently modulated CD4 and CD8 T-cell immunophenotype by inducing broad changes in their molecular pattern.
conclusionsWe provide a comprehensive functional and molecular characterization of T cells that are immunomodulated by BM-MSCs. Indeed, a better understanding of the immunological interplay between T cells and MSCs will facilitate the development of new efficient approaches to improve cell-based immune therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.