ArticleApplied and environmental microbiology2015
Discovery of a conjugative megaplasmid in Bifidobacterium breve.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Occurrence and applications of CRISPR-Cas systems in bifidobacteria.Applied and environmental microbiology · 2026Review
- Natural transformation drives large-scale genome mosaicism in human gut bifidobacteria.The ISME journal · 2026Article
- Genome-scale insights into the metabolic landscape and evolutionary development ofMicrobiome research reports · 2026Article
- Insights into toxin-antitoxin systems in the genusApplied and environmental microbiology · 2025Review
- HiBC: a publicly available collection of bacterial strains isolated from the human gut.Nature communications · 2025Article
- Molecular analysis of the replication functions of the bifidobacterial conjugative megaplasmid pMP7017.Microbial biotechnology · 2021Article
- Phylogenomic disentangling of theMicrobial genomics · 2021Article
- A Resource for Cloning and Expression Vectors Designed for Bifidobacteria: Overview of Available Tools and Biotechnological Applications.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Comparative Genomics Suggests Mechanisms of Genetic Adaptation toward the Catabolism of the Phenylurea Herbicide Linuron in Variovorax.Genome biology and evolution · 2020Article
- TheFrontiers in microbiology · 2019Article
- Editorial:Frontiers in microbiology · 2019Article
- Comparative genomics and genotype-phenotype associations in Bifidobacterium breve.Scientific reports · 2018Article
- Genomic diversity and distribution of Bifidobacterium longum subsp. longum across the human lifespan.Scientific reports · 2018Article
- Bifidobacteria and the infant gut: an example of co-evolution and natural selection.Cellular and molecular life sciences : CMLS · 2018Review
- Evaluation of genetic diversity among strains of the human gut commensal Bifidobacterium adolescentis.Scientific reports · 2016Article
- Bifidobacteria and Their Role as Members of the Human Gut Microbiota.Frontiers in microbiology · 2016Review
- Pangenome analysis of Bifidobacterium longum and site-directed mutagenesis through by-pass of restriction-modification systems.BMC genomics · 2015Article
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7 authors.
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Abstract
Bifidobacterium breve is a common and sometimes very abundant inhabitant of the human gut. Genome sequencing of B. breve JCM 7017 revealed the presence of an extrachromosomal element, designated pMP7017 consisting of >190 kb, thus representing the first reported bifidobacterial megaplasmid. In silico characterization of this element revealed several genomic features supporting a stable establishment of the megaplasmid in its host, illustrated by predicted CRISPR-Cas functions that are known to protect the host against intrusion of foreign DNA. Interestingly, pMP7017 is also predicted to encode a conjugative DNA transfer apparatus and, consistent with this notion, we demonstrate here the conjugal transfer of pMP7017 to representative strains of B. breve and B. longum subsp. longum. We also demonstrate the presence of a megaplasmid with homology to pMP7017 in three B. longum subsp. longum strains.
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