ArticleBMC genomics2014
Limited sex-biased neural gene expression patterns across strains in Zebrafish (Danio rerio).
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Sex-specific differences in zebrafish brains.Biology of sex differences · 2022Pooled it
- Telomerase Depletion Accelerates Ageing of the Zebrafish Brain.Aging cell · 2025Article
- Housing and husbandry factors affecting zebrafish novel tank test responses: a global multi-laboratory study.Lab animal · 2025Article
- Species variation in steroid hormone-related gene expression contributes to species diversity in sexually dimorphic communication in electric fishes.Hormones and behavior · 2024Article
- A maternal-to-zygotic-transition gene block on the zebrafish sex chromosome.G3 (Bethesda, Md.) · 2024Article
- First neurotranscriptome of adults Tambaquis (Colossoma macropomum) with characterization and differential expression between males and females.Scientific reports · 2024Article
- Transcriptomic signatures associated with underlying rapid changes in the early phase brain of bi-directional sex change inRoyal Society open science · 2023Article
- RNA-seq reveals potential gene biomarkers in fathead minnows (Environmental science. Processes & impacts · 2022Article
- A Glitch in the Matrix: The Role of Extracellular Matrix Remodeling in Opioid Use Disorder.Frontiers in integrative neuroscience · 2022Review
- Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning.Scientific reports · 2021Article
- Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour.BMC genomics · 2021Article
- Shedding new light on early sex determination in zebrafish.Archives of toxicology · 2020Article
- Differential effects of ethanol on behavior and GABAScientific reports · 2020Article
- Environmental Enrichment Improved Learning and Memory, Increased Telencephalic Cell Proliferation, and Induced Differential Gene Expression inFrontiers in pharmacology · 2020Article
- Age Bias in Zebrafish Models of Epilepsy: What Can We Learn From Old Fish?Frontiers in cell and developmental biology · 2020Review
- Transcriptome profiling analysis of sex-based differentially expressed mRNAs and lncRNAs in the brains of mature zebrafish (Danio rerio).BMC genomics · 2019Article
- Contextual fear learning and memory differ between stress coping styles in zebrafish.Scientific reports · 2019Article
- Stress, novel sex genes, and epigenetic reprogramming orchestrate socially controlled sex change.Science advances · 2019Article
- Differences in stress reactivity between zebrafish with alternative stress coping styles.Royal Society open science · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMale and female vertebrates typically differ in a range of characteristics, from morphology to physiology to behavior, which are influenced by factors such as the social environment and the internal hormonal and genetic milieu. However, sex differences in gene expression profiles in the brains of vertebrates are only beginning to be understood. Fishes provide a unique complement to studies of sex differences in mammals and birds given that fish show extreme plasticity and lability of sexually dimorphic characters and behaviors during development and even adulthood. Hence, teleost models can give additional insight into sexual differentiation. The goal of this study is to identify neurotranscriptomic mechanisms for sex differences in the brain.
resultsIn this study we examined whole-brain sex-biased gene expression through RNA-sequencing across four strains of zebrafish. We subsequently conducted systems level analyses by examining gene network dynamics between the sexes using weighted gene coexpression network analysis. Surprisingly, only 61 genes (approximately 0.4% of genes analyzed) showed a significant sex effect across all four strains, and 48 of these differences were male-biased. Several of these genes are associated with steroid hormone biosynthesis. Despite sex differences in a display of stress-related behaviors, basal transcript levels did not predict the intensity of the behavioral display. WGCNA revealed only one module that was significantly associated with sex. Intriguingly, comparing intermodule dynamics between the sexes revealed only moderate preservation. Further we identify sex-specific gene modules.
conclusionsDespite differences in morphology, physiology, and behavior, there is limited sex-biased neural gene expression in zebrafish. Further, genes found to be sex-biased are associated with hormone biosynthesis, suggesting that sex steroid hormones may be key contributors to sexual behavioral plasticity seen in teleosts. A possible mechanism is through regulating specific brain gene networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.