Trial reportClinical research in cardiology : official journal of the German Cardiac Society2015
Beneficial effects of renal sympathetic denervation on cardiovascular inflammation and remodeling in essential hypertension.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Reductions of left ventricular mass and atrial size following renal denervation: a meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Pooled it
- Neuropeptide Y as an indicator of successful alterations in sympathetic nervous activity after renal sympathetic denervation.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Trial
- Norepinephrine promotes oxidative stress in vascular adventitial fibroblasts via PKC/NFκB-mediated NOX2 upregulation.Redox report : communications in free radical research · 2025Article
- Biomarkers for Predicting Blood Pressure Response to Renal Denervation.Current hypertension reports · 2025Review
- Sympathetic Nervous System and Atherosclerosis.International journal of molecular sciences · 2023Review
- The Effect of Renal Denervation on T Cells in Patients with Resistant Hypertension.International journal of molecular sciences · 2023Article
- Dynamics of Soluble Factors and Double-Negative T Cells Associated with Response to Renal Denervation in Resistant Hypertension Patients.Journal of personalized medicine · 2022Article
- Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies.Frontiers in cell and developmental biology · 2021Review
- Effect of Renal Denervation on Cardiac Function and Inflammatory Factors in Heart Failure After Myocardial Infarction.Journal of cardiovascular pharmacology · 2020Article
- Evaluation of changes in left ventricular structure and function in hypertensive patients with coronary artery disease after PCI using real-time three-dimensional echocardiography.Experimental and therapeutic medicine · 2018Article
- Impact of renal denervation on tissue NaClinical research in cardiology : official journal of the German Cardiac Society · 2018Observational
- Target blood pressure in high risk cardiovascular patients.Journal of thoracic disease · 2017Article
- Anti-Inflammatory Effects and Prediction of Blood Pressure Response by Baseline Inflammatory State in Catheter-Based Renal Denervation.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Increased Circulating Tissue Inhibitor of Metalloproteinase-2 Is Associated With Resistant Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Second denervation in a patient with resistant hypertension.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Prevalence of thrombophilic disorders in takotsubo patients: the (ThROmbophylia in TAkotsubo cardiomyopathy) TROTA study.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Renal sympathetic denervation in therapy resistant hypertension - pathophysiological aspects and predictors for treatment success.World journal of cardiology · 2016Review
- Effect of Renal Sympathetic Denervation on Specific MicroRNAs as an Indicator of Reverse Remodeling Processes in Hypertensive Heart Disease.Journal of clinical hypertension (Greenwich, Conn.) · 2016Observational
- Renal artery sympathetic denervation: observations from the UK experience.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Uninephrectomy-Induced Lipolysis and Low-Grade Inflammation Are Mimicked by Unilateral Renal Denervation.Frontiers in physiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRenal sympathetic denervation (RSD) represents a potential treatment option for certain patients with resistant arterial hypertension (HT). HT is associated with chronic vascular inflammation and remodeling, contributing to progressive vascular damage, and atherosclerosis. The present study aimed to evaluate the influence of RSD on cardiovascular inflammation and remodeling by determining serum levels of interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP), matrix metalloproteinases (MMP), and tissue inhibitor of metalloproteinases (TIMP).
methodsA total of 60 consecutive patients (age 67.9 ± 9.6 years) undergoing RSD were included. A therapeutic response was defined as an office systolic blood pressure (SBP) reduction of >10 mmHg 6 months after RSD. Venous serum samples for measurement of hsCRP, IL-6, MMP-2, MMP-9, and TIMP-1 were collected prior to and 6 months after RSD.
resultsA significant reduction in office SBP of 26.4 mmHg [SBPbaseline 169.3 mmHg (SD 11.3), p < 0.001] was documented 6 months after RSD. The serum levels of hsCRP (p < 0.001) and the pro-inflammatory cytokine IL-6 (p < 0.001) were significantly decreased compared to baseline values. The levels of MMP-9 (p = 0.024) and MMP-2 (p < 0.01) were significantly increased compared to baseline values.
conclusionIn addition to the effective blood pressure reduction in response to RSD, this study demonstrates a positive effect of RSD on biomarkers reflecting vascular inflammation and remodeling. These results suggest a possible prognostic benefit of RSD in high-risk patients for endothelial dysfunction and cardiovascular remodeling as well as end-organ damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.