ArticleHistochemistry and cell biology2015
Ontogenic development of nerve fibers in human fetal livers: an immunohistochemical study using neural cell adhesion molecule (NCAM) and neuron-specific enolase (NSE).
Article in Histochemistry and cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Development of the nervous system in mouse liver.World journal of hepatology · 2022Article
- Innervation of the proximal human biliary tree.Virchows Archiv : an international journal of pathology · 2020Article
- Increased serum total bilirubin-albumin ratio was associated with bilirubin encephalopathy in neonates.Bioscience reports · 2020Article
- A case of small hepatocellular carcinoma with malignant ductular reaction.International journal of clinical and experimental pathology · 2020Article
- A Retrospective Case Control Study of Ductal Plate Malformation-like Features in Consecutive 200 Autopsies.Pathology oncology research : POR · 2018Article
- The Histochemistry and Cell Biology omnium-gatherum: the year 2015 in review.Histochemistry and cell biology · 2016Review
- Hepatobiliary cystadenocarcinoma of the liver with features of ductal plate malformations.Journal of gastrointestinal cancer · 2015Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
The aim of the study was to investigate nerve fibers (NF) in human fetal livers. An immunohistochemical study was performed. NF were classified into portal tract innervation (PoI) and parenchymal innervation (PaI). The hilum area showed many Pol NF at 7 GW, and NF increased with gestational week (GW). Direct innervations to biliary epithelium were recognized. In large portal tracts, a few NCAM-positive mesenchymal cells were seen at 8 GW and many mesenchymal cells were noted around 12 GW. Apparent NF emerged around 15 GW, and NF increased with GW. Many NF plexuses were seen in 30-40 GW. In small portal tracts, no NF were seen in 7-10 GW. A few NCAM-positive mesenchymal cells emerged in 11 GW, and they increased thereafter. Apparent NF were seen around 20 GW and NF increased with GW. At term (40 GW), PoI NF were still immature. Ductal plate (DP) was positive for NCAM, NSE, chromogranin and synaptophysin, and direct innervations to DP were seen. The direct innervations to developing bile ducts and peribiliary glands were also seen. PaI NF were first seen at 21 GW and was consistent until 40 GW in which a few NF were seen in PaI. These observations suggest that PoI NF arise from committed portal mesenchyme. PaI NF are very immature at 40 GW. There are direct innervations to bile ducts, peribiliary glands, portal veins, hepatic arteries, and DP.
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