ArticleSocial cognitive and affective neuroscience2015
OXTR polymorphism predicts social relationships through its effects on social temperament.
Article in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- A test of the stress-buffering model of social support in smoking cessation: is the relationship between social support and time to relapse mediated by reduced withdrawal symptoms?Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Trial
- Epigenetics of Chronic Stress: Mechanisms and Health Impacts.Current genomics · 2025Review
- Article
- An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social-emotional mediators.Development and psychopathology · 2021Article
- Neurobiological Bases of Social Networks.Frontiers in psychology · 2021Review
- Evidence for Association Between OXTR Gene and ASD Clinical Phenotypes.Journal of molecular neuroscience : MN · 2018Article
- Social discomfort moderates the relationship between drinking in response to negative affect and solitary drinking in underage drinkers.Addictive behaviors · 2018Article
- The Influence of Genetic Variation on Social Disposition, Romantic Relationships and Social Networks: a Replication Study.Adaptive human behavior and physiology · 2018Article
- Youth temperament, harsh parenting, and variation in the oxytocin receptor gene forecast allostatic load during emerging adulthood.Development and psychopathology · 2017Article
- Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Common variant in OXTR predicts growth in positive emotions from loving-kindness training.Psychoneuroendocrinology · 2016Article
- Environmental influence in the brain, human welfare and mental health.Nature neuroscience · 2015Review
- Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Humans have a fundamental need for strong interpersonal bonds, yet individuals differ appreciably in their degree of social integration. That these differences are also substantially heritable has spurred interest in biological mechanisms underlying the quality and quantity of individuals' social relationships. We propose that polymorphic variation in the oxytocin receptor gene (OXTR) associates with complex social behaviors and social network composition through intermediate effects on negative affectivity and the psychological processing of socially relevant information. We tested a hypothesized social cascade from the molecular level (OXTR variation) to the social environment, through negative affectivity and inhibited sociality, in a sample of 1295 men and women of European American (N = 1081) and African American (N = 214) ancestry. Compared to European Americans having any T allele of rs1042778, individuals homozygous for the alternate G allele reported significantly lower levels of negative affectivity and inhibited sociality, which in turn predicted significantly higher levels of social support and a larger/more diverse social network. Moreover, the effect of rs1042778 variation on social support was fully accounted for by associated differences in negative affectivity and inhibited sociality. Results replicated in the African American sample. Findings suggest that OXTR variation modulates levels of social support via proximal impacts on individual temperament.
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