ReviewGastroenterology report2015
The present and the future in the diagnosis and management of celiac disease.
Review in Gastroenterology report, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Immune-Mediated Association Between Celiac Disease and Sensorineural Hearing Loss: A Systematic Narrative Review.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022Pooled it
- Quality of Life and Gluten-Free Diet Adherence in Adult Patients with Celiac Disease: A Cross-Sectional Questionnaire Study.Nutrients · 2026Article
- Evaluation of Novel Immunohistochemical Biomarkers for the Diagnosis of Celiac Disease Demonstrates the Utility of TCRδ Immunostaining.Diagnostics (Basel, Switzerland) · 2026Article
- Celiac disease in children with focus on symptoms and quality of life.Scientific reports · 2025Article
- Molecularly Imprinted Polymer Advanced Hydrogels as Tools for Gastrointestinal Diagnostics.Gels (Basel, Switzerland) · 2025Review
- Article
- Synchronous colonal and jejunal adenocarcinomas leading to intussusception in an adult female suffering from celiac disease.Journal of surgical case reports · 2023Article
- Article
- Celiac Disease Revisited.GE Portuguese journal of gastroenterology · 2022Review
- Healthcare Resource Utilization and Costs in Celiac Disease: A US Claims Analysis.The American journal of gastroenterology · 2020Article
- Diagnosis and Treatment Patterns in Celiac Disease.Digestive diseases and sciences · 2019Review
- Non-Invasive Biomarkers for Celiac Disease.Journal of clinical medicine · 2019Review
- Novel Nondietary Therapies for Celiac Disease.Cellular and molecular gastroenterology and hepatology · 2019Review
- Cognitive Impairment and Celiac Disease: Is Transcranial Magnetic Stimulation aInternational journal of molecular sciences · 2018Review
- A Serological Diagnosis of Coeliac Disease Is Associated with Osteoporosis in Older Australian Adults.Nutrients · 2018Article
- The intestinal barrier: a fundamental role in health and disease.Expert review of gastroenterology & hepatology · 2017Review
- Celiac disease: from etiological factors to evolving diagnostic approaches.Journal of gastroenterology · 2017Review
- Coeliac disease in infants: antibodies to deamidated gliadin peptide come first!Italian journal of pediatrics · 2017Article
- Coeliac disease screening is suboptimal in a tertiary gastroenterology setting.Postgraduate medical journal · 2017Article
- Splenic volume differentiates complicated and non-complicated celiac disease.United European gastroenterology journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Celiac disease is an autoimmune enteropathy caused by gluten in genetically predisposed individuals. In celiac disease, adaptive and innate immune activation results in intestinal damage and a wide range of clinical manifestations. In the past, celiac disease was thought to result in signs and symptoms solely related to the gastrointestinal tract. Now, more than half of the adult population presents with extra-intestinal manifestations that can also be expected to improve on a gluten-free diet. For this reason, it is recommended that physicians have a low threshold of suspicion for celiac disease. Current knowledge of the immune pathogenesis of this autoimmune disease has served as a catalyst for the development of novel diagnostic tools and therapeutics. Over the years, highly sensitive and specific serological assays, in addition to genetic markers, have been found to target specific steps in the cascade pathway of celiac disease. Also the advent of the gluten challenge has enabled experts to design diagnostic algorithms and monitor clinical responses in clinical trials. The gluten challenge has provided substantial benefit in the advance of novel therapeutics as an adjuvant treatment to the gluten free diet. Generally, a strict gluten-free diet is highly burdensome to patients and can be limited in its efficacy. Alternative therapies-including gluten modification, modulation of intestinal permeability and immune response-could be central to the future treatment of celiac disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.