ArticleMarine drugs2014
Butrepyrazinone, a new pyrazinone with an unusual methylation pattern from a Ghanaian Verrucosispora sp. K51G.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Verrucacrylic Acids A and B From a Marine Sponge-derived Verrucosispora sp. FIM06025.Chemistry & biodiversity · 2026Article
- Identification and heterologous expression of an NRPS biosynthetic gene cluster responsible for the production of the pyrazinones Ichizinone A, B and C.Microbial cell factories · 2025Article
- Deciphering the Biosynthesis and Physiological Function of 5-Methylated Pyrazinones Produced by Myxobacteria.ACS central science · 2024Article
- Identification of Novel and Safe Fungicidal Molecules againstBioMed research international · 2022Article
- Enhypyrazinones A and B, Pyrazinone Natural Products from a Marine-Derived MyxobacteriumMarine drugs · 2019Article
- Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products.Marine drugs · 2019Review
- Diversity, Novelty, and Antimicrobial Activity of Endophytic Actinobacteria From Mangrove Plants in Beilun Estuary National Nature Reserve of Guangxi, China.Frontiers in microbiology · 2018Article
- Verrucosispora rhizosphaerae sp. nov., isolated from mangrove rhizosphere soil.Antonie van Leeuwenhoek · 2018Article
- Nucleophilic and electrophilic cyclization ofBeilstein journal of organic chemistry · 2017Article
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7 authors.
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Abstract
We report the structural characterization of a new pyrazinone analogue; butrepyrazinone, which was isolated from a new actinomycete strain Verrucosispora sp. K51G recovered from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of a compound from the fermentation culture and a combination of NMR spectroscopy, high-resolution mass spectrometry and computer-aided calculations revealed that butrepyrazinone (10) possesses an unusual methylation pattern on the pyrazinone ring. Butrepyrazinone (10), however, displayed no antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains, suggesting that 10 may act as a signal molecule for this strain. Although the same molecule has been synthesized previously, this is the first report to disclose the discovery of butrepyrazinone (10) from nature.
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