SynthesisJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2015
Diagnostic capability of biological markers in assessment of obstructive sleep apnea: a systematic review and meta-analysis.
Synthesis in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Pooled it
- Association between obstructive sleep apnea and health-related quality of life in untreated adults: a systematic review.Sleep & breathing = Schlaf & Atmung · 2021Pooled it
- Epigenetics of obstructive sleep apnea syndrome: a systematic review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Pooled it
- Diagnostic accuracy of panoramic radiography in the detection of calcified carotid artery atheroma: a meta-analysis.Clinical oral investigations · 2019Pooled it
- Diagnostic validity of methods for assessment of swallowing sounds: a systematic review.Brazilian journal of otorhinolaryngologyPooled it
- Is video demonstration for type III sleep studies performance worse than technical face-to-face teaching?Sleep & breathing = Schlaf & Atmung · 2024Trial
- Diagnostic accuracy of biological markers for detecting obstructive sleep apnoea.The Cochrane database of systematic reviews · 2026Article
- Diagnostic modulation of subgingival proteomic biomarkers by age and smoking habits in periodontitis.Journal of periodontology · 2026Article
- Mild Cognitive Impairment Associated with Obstructive Sleep Apnoea: A Pilot Study on Oxygen-Related Plasma Biomarkers and Network Analysis.Molecular neurobiology · 2026Article
- Diversity and random forest models of oral microbiomes in periodontal health using publicly available data.Journal of periodontology · 2026Article
- Review
- Usefulness of Blood Biomarkers in Screening Patients with Obstructive Sleep Apnea: Could Albumin Indices and Uric Acid-to-HDL Ratio Be New OSAS Severity Indices?Advances in respiratory medicine · 2025Article
- Temporal changes in blood biomarkers associated with sleep apnoea severity: a retrospective cohort study in Finland.BMJ open · 2025Article
- Diagnostic Accuracy of Novel Protein Biomarkers in Saliva to Detect Periodontitis Using Untargeted 'SWATH' Mass Spectrometry.Journal of clinical periodontology · 2025Article
- The pulse of sleep: novel interventions in understanding the sleep-cardiovascular connection: a literature review.Annals of medicine and surgery (2012) · 2024Review
- The salivary microbiome as a diagnostic biomarker of periodontitis: a 16S multi-batch study before and after the removal of batch effects.Frontiers in cellular and infection microbiology · 2024Article
- Investigating the Role of Serum and Plasma IL-6, IL-8, IL-10, TNF-alpha, CRP, and S100B Concentrations in Obstructive Sleep Apnea Diagnosis.International journal of molecular sciences · 2023Article
- Diagnosis of Paediatric Obstructive Sleep-Disordered Breathing beyond Polysomnography.Children (Basel, Switzerland) · 2023Review
- Surface Active Salivary Metabolites Indicate Oxidative Stress and Inflammation in Obstructive Sleep Apnea.Allergy, asthma & immunology research · 2023Article
- Osteoprotegerin, Chitinase 3-like Protein 1, and Cardiotrophin-1 as Potential Biomarkers of Obstructive Sleep Apnea in Adults-A Case-Control Study.International journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 4 countries.
Funding
Abstract
objectiveThe purpose of this systematic review is to evaluate the diagnostic value of biological markers (exhaled breath condensate, blood, salivary and urinary) in the diagnosis of OSA in comparison to the gold standard of nocturnal PSG.
methodsStudies that differentiated OSA from controls based on PSG results, without age restriction, were eligible for inclusion. The sample of selected studies could include studies in obese patients and with known cardiac disease. A detailed individual search strategy for each of the following bibliographic databases was developed: Cochrane, EMBASE, MEDLINE, PubMed, and LILACS. The references cited in these articles were also crosschecked and a partial grey literature search was undertaken using Google Scholar. The methodology of selected studies was evaluated using the 14-item Quality Assessment Tool for Diagnostic Accuracy Studies.
resultsAfter a two-step selection process, nine articles were identified and subjected to qualitative and quantitative analyses. Among them, only one study conducted in children and one in adults found biomarkers that exhibit sufficiently satisfactory diagnostic accuracy that enables application as a diagnostic method for OSA.
conclusionKallikrein-1, uromodulin, urocotin-3, and orosomucoid-1 when combined have enough accuracy to be an OSA diagnostic test in children. IL-6 and IL-10 plasma levels have potential to be good biomarkers in identifying or excluding the presence of OSA in adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.