Evidence map›Paper›PMID 25325534›Full record

ArticleJournal of child and adolescent psychopharmacology2015

Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): recommendations from the 2013 PANS Consensus Conference.

Kiki Chang, Jennifer Frankovich, Michael Cooperstock, Madeleine W Cunningham, M Elizabeth Latimer, Tanya K Murphy, Mark Pasternack, Margo Thienemann, Kyle Williams, Jolan Walter and 2 more

3 registry-linked trialsAbstract readConsensus Statement
In one paragraph

Article in Journal of child and adolescent psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 152 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02889016 recruitingnot on this map

Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS

TypeobservationalSponsorStanford UniversityRan2013 to 2028Enrolled500ConditionsPediatric Acute-Onset Neuropsychiatric Syndrome, Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections, PANS, PANDAS
NCT03348618 phase4unknown statusnot on this mapstarted 2017, after this paper: background citation

A Multi-site, Open-Label, Pilot Study to Evaluate the Benefit of Octagam 5%® in Subjects With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)

TypeinterventionalSponsorIMMUNOe Research CentersRan2017 to 2020Enrolled21ConditionsPediatric Acute-Onset Neuropsychiatric Syndrome, Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal InfectionsArmsIVIG
NCT03507218 terminatednot on this mapstarted 2018, after this paper: background citation

Clinical, Laboratory, and Biomedical Characterization of Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)

TypeobservationalSponsorNational Institute of Mental Health (NIMH)Ran2018 to 2019Enrolled9ConditionsPediatric Acute-onset Neuropsychiatric Syndrome (PANS)
3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Guideline
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  5. Medicinal cannabis plant extract (NTI164) modifies epigenetic, ribosomal, and immune pathways in paediatric acute-onset neuropsychiatric syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kiki Chang1 Professor of Psychiatry, Director of the Pediatric Bipolar Disorders Program, Stanford University School of Medicine , Stanford, CA.
Jennifer Frankovich
Michael Cooperstock
Madeleine W Cunningham
M Elizabeth Latimer
Tanya K Murphy
Mark Pasternack
Margo Thienemann
Kyle Williams
Jolan Walter
Susan E Swedo
PANS Collaborative Consortium

Funding

Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Evaluation and Treatment of Obsessive Compulsive and Related DisordersZIAMH002666 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SWEDO, SUSAN · 2009 to 2019
$7.6M
AUTOIMMUNE DETERMINANTS OF HUMAN CARDIAC MYOSINR01HL056267 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI COOPER, LESLIE T, CUNNINGHAM, MADELEINE W. · 1997 to 2013
$4.7M
MYOSIN--A LINK BETWEEN STREPTOCOCCI AND HEARTR37HL035280 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CUNNINGHAM, MADELEINE W. · 1999 to 2008
$3.0M
Brain Connectivity and Mindfulness Training in Youth with Bipolar Disorder NOSK24MH101260 · NIMH · STANFORD UNIVERSITY · PI CHANG, KIKI D · 2013 to 2014
$358k
NCATS NIH HHS UL1 TR000142NHLBI NIH HHS R01 HL056267NHLBI NIH HHS R37 HL035280NIMH NIH HHS K24 MH101260
6 · The paper itself

Abstract

On May 23 and 24, 2013, the First PANS Consensus Conference was convened at Stanford University, calling together a geographically diverse group of clinicians and researchers from complementary fields of pediatrics: General and developmental pediatrics, infectious diseases, immunology, rheumatology, neurology, and child psychiatry. Participants were academicians with clinical and research interests in pediatric autoimmune neuropsychiatric disorder associated with streptococcus (PANDAS) in youth, and the larger category of pediatric acute-onset neuropsychiatric syndrome (PANS). The goals were to clarify the diagnostic boundaries of PANS, to develop systematic strategies for evaluation of suspected PANS cases, and to set forth the most urgently needed studies in this field. Presented here is a consensus statement proposing recommendations for the diagnostic evaluation of youth presenting with PANS.

Indexed as

Acute DiseaseAutoimmune DiseasesChildHumansObsessive-Compulsive DisorderPractice Guidelines as TopicStreptococcal InfectionsSyndrome

Identifiers

PMID25325534
PMCPMC4340805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.