ArticleSleep2014
Gray matter-specific changes in brain bioenergetics after acute sleep deprivation: a 31P magnetic resonance spectroscopy study at 4 Tesla.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Hemispheric asymmetry in high-energy phosphate consumption during sleep-deprivation is balanced by creatine.Frontiers in neuroscience · 2025Article
- Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation.Scientific reports · 2024Article
- The potential link between obstructive sleep apnea and postoperative neurocognitive disorders: current knowledge and possible mechanisms.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022Review
- Brain Energy Deficit as a Source of Oxidative Stress in Migraine: A Molecular Basis for Migraine Susceptibility.Neurochemical research · 2021Review
- The effect of jet lag on the human brain: A neuroimaging study.Human brain mapping · 2020Article
- Altered Percent Amplitude of Fluctuation in Healthy Subjects After 36 h Sleep Deprivation.Frontiers in neurology · 2020Article
- Phosphocreatine Levels in the Left Thalamus Decline during Wakefulness and Increase after a Nap.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Sleep/wake movement velocities, trajectories and micro-arousals during maturation in rats.BMC neuroscience · 2017Article
- Time is ripe: maturation of metabolomics in chronobiology.Current opinion in biotechnology · 2017Review
- Neuroplasticity and Clinical Practice: Building Brain Power for Health.Frontiers in psychology · 2016Review
- The energetic cost of a night on the town.Sleep · 2014Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
STUDY
objectivesA principal function of sleep may be restoration of brain energy metabolism caused by the energetic demands of wakefulness. Because energetic demands in the brain are greater in gray than white matter, this study used linear mixed-effects models to examine tissue-type specific changes in high-energy phosphates derived using 31P magnetic resonance spectroscopy (MRS) after sleep deprivation and recovery sleep.
designExperimental laboratory study.
settingOutpatient neuroimaging center at a private psychiatric hospital.
participantsA total of 32 MRS scans performed in eight healthy individuals (mean age 35 y; range 23-51 y).
interventionsPhosphocreatine (PCr) and β-nucleoside triphosphate (NTP) were measured using 31P MRS three dimensional-chemical shift imaging at high field (4 Tesla) after a baseline night of sleep, acute sleep deprivation (SD), and 2 nights of recovery sleep. Novel linear mixed-effects models were constructed using spectral and tissue segmentation data to examine changes in bioenergetics in gray and white matter. MEASUREMENTS AND
resultsPCr increased in gray matter after 2 nights of recovery sleep relative to SD with no significant changes in white matter. Exploratory analyses also demonstrated that increases in PCr were associated with increases in electroencephalographic slow wave activity during recovery sleep. No significant changes in β-NTP were observed.
conclusionsThese results demonstrate that sleep deprivation and subsequent recovery-induced changes in high-energy phosphates primarily occur in gray matter, and increases in PCr after recovery sleep may be related to sleep homeostasis.
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Registered trials
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