Evidence map›Paper›PMID 25325501›Full record

Observational studySleep2015

Rapid eye movement sleep behavior disorder: a window on the emotional world of Parkinson disease.

Paolo Mariotti, Davide Quaranta, Raffaella Di Giacopo, Anna Rita Bentivoglio, Marianna Mazza, Annalisa Martini, Jorge Canestri, Giacomo Della Marca

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Non-motor symptoms are associated with REM sleep behavior disorder in Parkinson's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
  3. Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Paolo MariottiUnit of Child Neuropsychiatry, Catholic University, Rome, Italy.
Davide QuarantaInstitute of Neurology, Catholic University, Rome, Italy.
Raffaella Di GiacopoInstitute of Neurology, Catholic University, Rome, Italy.
Anna Rita BentivoglioInstitute of Neurology, Catholic University, Rome, Italy.
Marianna MazzaInstitute of Psychiatry, Catholic University, Rome, Italy.
Annalisa MartiniInstitute of Psychiatry, Catholic University, Rome, Italy.
Jorge CanestriInternational Psychoanalytical Association and Italian Psychoanalytical Association.
Giacomo Della MarcaInstitute of Neurology, Catholic University, Rome, Italy.
Università Cattolica del Sacro Cuore · ITInternational Psychoanalytical Association · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesREM sleep behavior disorder (RBD) is a parasomnia characterized by motor activity during sleep with dream mentation. Aggressiveness has been considered a peculiar feature of dreams associated with RBD, despite normal score in aggressiveness scales during wakefulness. We aimed to measure daytime aggressiveness and analyze dream contents in a population of patients with Parkinson disease (PD) with and without RBD.

designThis is a single-center prospective observational study; it concerns the description of the clinical features of a medical disorder in a case series.

settingThe study was performed in the Department of Neurosciences of the Catholic University in Rome, Italy. PATIENTS: Three groups of subjects were enrolled: patients with PD plus RBD, patients with PD without RBD, and healthy controls.

interventionsThe diagnosis of RBD was determined clinically and confirmed by means of overnight, laboratory-based video-polysomnography. For the evaluation of diurnal aggressiveness, the Buss-Perry Aggression Questionnaire (BPAQ) was used. The content of dreams was evaluated by means of the methods of Hall and Van De Castle. MEASUREMENTS AND

resultsPatients with PD without RBD displayed higher levels of anger, and verbal and physical aggressiveness than patients with PD and RBD and controls. Patients with PD and RBD and controls did not differ in hostility.

conclusionsIt can be hypothesized that a noradrenergic impairment at the level of the locus coeruleus could, at the same time, explain the presence of RBD, as well as the reduction of diurnal aggressiveness. This finding also suggests a role for REM sleep in regulating homeostasis of emotional brain function.

Indexed as

EmotionsAgedAggressionCase-Control StudiesDreamsFemaleHumansItalyLocus CoeruleusMaleParkinson DiseasePolysomnographyProspective StudiesREM Sleep Behavior DisorderSleep, REMSurveys and QuestionnairesaggressivenessdreamsParkinson DiseaseREM Behavior Disordersleep

Identifiers

PMID25325501
PMCPMC4288610
OpenAlexW1995328463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.