Evidence map›Paper›PMID 25325491›Full record

Trial reportSleep2014

Psychometric performance and responsiveness of the functional outcomes of sleep questionnaire and sleep apnea quality of life instrument in a randomized trial: the HomePAP study.

Martha E Billings, Carol L Rosen, Dennis Auckley, Ruth Benca, Nancy Foldvary-Schaefer, Conrad Iber, Phyllis C Zee, Susan Redline, Vishesh K Kapur

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00642486 nacompletednot on this map

Portable Monitoring in the Diagnosis and Management of Obstructive Sleep Apnea

TypeinterventionalSponsorCase Western Reserve UniversityRan2008 to 2010Enrolled373ConditionsSleep Apnea, ObstructiveArmsPortable (Embla Embletta X30 system and Respironic REMStar Auto M series with CFlex), Standard polysomnography (PSG)
NCT01482351 nacompletednot on this map

Mild Cognitive Impairment and Obstructive Sleep Apnea

TypeinterventionalSponsorGeorge Mason UniversityRan2012 to 2014Enrolled54ConditionsObstructive Sleep Apnea, Mild Cognitive ImpairmentArmsCPAP adherence intervention, Attention control intervention
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Predicting EuroQol (EQ-5D-5 L) health state utilities from functional outcomes of sleep questionnaire (FOSQ-10) scores.The European journal of health economics : HEPAC : health economics in prevention and care · 2026
    Article
  11. Developing and testing a patient-reported outcome measure for patients with sleep disturbances using EQ-5D and condition-specific bolt-ons: a mixed method study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  12. Review
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  16. International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023
    Review
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martha E BillingsUW Medicine Sleep Center, Division of Pulmonary Critical Care, University of Washington, Seattle, WA.
Carol L RosenCase Western Reserve University, School of Medicine, Cleveland, OH: Rainbow Babies and Children's Hospital, University Hospitals, Case Medical Center, Cleveland, OH.
Dennis AuckleyCase Western Reserve University, School of Medicine, Cleveland, OH: Center for Sleep Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, MetroHealth Medical Center, Cleveland, OH.
Ruth BencaDepartment of Psychiatry, University of Wisconsin, Madison, WI.
Nancy Foldvary-SchaeferCase Western Reserve University, School of Medicine, Cleveland, OH: Cleveland Clinic, Cleveland, OH.
Conrad IberHennepin County Medical Center, University of Minnesota, Minneapolis, MN.
Phyllis C ZeeNorthwestern University, Feinberg School of Medicine, Chicago, IL.
Susan RedlineBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Vishesh K KapurUW Medicine Sleep Center, Division of Pulmonary Critical Care, University of Washington, Seattle, WA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesMeasures of health-related quality of life (HRQL) specific for sleep disorders have had limited psychometric evaluation in the context of randomized controlled trials (RCTs). We investigated the psychometric properties of the Functional Outcomes of Sleep Questionnaire (FOSQ) and Sleep Apnea Quality of Life Instrument (SAQLI). We evaluated the FOSQ and SAQLI construct and criterion validity, determined a minimally important difference, and assessed for associations of responsiveness to baseline subject characteristics and continuous positive airway pressure (CPAP) adherence in a RCT population.

designSecondary analysis of data collected in a multisite RCT of home versus laboratory-based diagnosis and treatment of obstructive sleep apnea (HomePAP trial).

participantsIndividuals enrolled in the HomePAP trial (n = 335).

interventionsN/A. MEASUREMENT AND

resultsThe FOSQ and SAQLI subscores demonstrated high reliability and criterion validity, correlating with Medical Outcomes Study 36-Item Short Form Survey domains. Correlations were weaker with the Epworth Sleepiness Scale (ESS). Both the FOSQ and SAQLI scores improved after 3 mo with CPAP therapy. Averaging 4 h or more of CPAP use was associated with an increase in the FOSQ beyond the minimally important difference. Baseline depressive symptoms and sleepiness predicted FOSQ and SAQLI responsiveness; demographic, objective obstructive sleep apnea (OSA) severity and sleep habits were not predictive in linear regression.

conclusionsThe FOSQ and SAQLI are responsive to CPAP intervention, with the FOSQ being more sensitive to differences in CPAP adherence than the SAQLI. These instruments provide unique information about health outcomes beyond that provided by changes in physiological measures of OSA severity (apnea-hypopnea index). CLINICAL TRIAL INFORMATION: Portable Monitoring for Diagnosis and Management of Sleep Apnea (HomePAP) URL: http://clinicaltrials.gov/show/NCT00642486. NIH clinical trials registry number: NCT00642486.

Indexed as

Continuous Positive Airway PressureQuality of LifeSurveys and QuestionnairesFemaleHumansMaleMiddle AgedPatient CompliancePsychometricsReproducibility of ResultsSleepSleep Apnea, ObstructiveTreatment Outcomehealth-related quality of lifepsychometricssleep apnea

Identifiers

PMID25325491
PMCPMC4548522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.