ArticleSleep2015
Usefulness of a Nocturnal SOREMP for Diagnosing Narcolepsy with Cataplexy in a Pediatric Population.
Article in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Rapid Eye Movement Sleep-Related Indicators with Promising Performance in Diagnosing Narcolepsy.Nature and science of sleep · 2026Article
- Clinical significance of nocturnal sleep onset REM periods in narcolepsy diagnosis and diagnostic stability.Sleep and biological rhythms · 2026Article
- Narcolepsy: Pathophysiology, Diagnosis, Management, and Future Directions, a Narrative Review.Brain and behavior · 2025Review
- Present and Future of Central Disorders of Hypersomnolence.Journal of sleep research · 2025Review
- Quantification of electromyographic activity during REM sleep in Chinese narcolepsy patients and healthy controls: a comparative study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Narcolepsy and rapid eye movement sleep.Journal of sleep research · 2025Review
- Validation of a Wireless, Self-Applied Device for Sleep Recording in the Paediatric Population.Nature and science of sleep · 2025Article
- Exploring sleep characteristics in Chinese patients with narcolepsy: insights from the nocturnal sleep onset rapid eye movement period (nSOREMP).Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Recommended protocols for the Multiple Sleep Latency Test and Maintenance of Wakefulness Test in children: guidance from the American Academy of Sleep Medicine.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Sleep Stage Transitions and Sleep-Dependent Memory Consolidation in Children with Narcolepsy-Cataplexy.Children (Basel, Switzerland) · 2023Article
- Snoring was related to self-reported daytime sleepiness and tiredness in young adults performing compulsory conscript service.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Defining disrupted nighttime sleep and assessing its diagnostic utility for pediatric narcolepsy type 1.Sleep · 2020Article
- The neurobiological basis of narcolepsy.Nature reviews. Neuroscience · 2019Review
- Comparison of the macro and microstructure of sleep in a sample of sleep clinic hypersomnia cases.Neurobiology of sleep and circadian rhythms · 2019Article
- Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy.Nature communications · 2018Article
- Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy.Neurobiology of disease · 2018Article
- Nocturnal REM Sleep Without Atonia Is a Diagnostic Biomarker of Pediatric Narcolepsy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- The MSLT is Repeatable in Narcolepsy Type 1 But Not Narcolepsy Type 2: A Retrospective Patient Study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Sleep-stage transitions during polysomnographic recordings as diagnostic features of type 1 narcolepsy.Sleep medicine · 2015Article
- How Can We Better Leverage the Nocturnal Polysomnogram in the Diagnosis of Childhood-Onset Narcolepsy?Sleep · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesWe investigated the diagnostic accuracy of a nocturnal sleep onset rapid eye movement sleep period (nSOREMP) for the identification of narcolepsy with cataplexy (N+C) among children and adolescents referred to the sleep laboratory for an overnight polysomnography (PSG) and multiple sleep latency test (MSLT).
designRetrospective chart review of sleep clinic notes and PSG and MSLT reports.
settingBoston Children's Hospital sleep laboratory and outpatient clinics. PATIENTS: All patients 6-18 y old, referred for consecutive PSG and MSLT for the evaluation of central hypersomnias, between January 2005 and January 2014. MEASUREMENTS AND
resultsWe analyzed the records of 148 patients and established diagnostic categories using the International Classification of Sleep Disorders, 2(nd) Edition. Patient diagnoses included narcolepsy with cataplexy (28.4%), narcolepsy without cataplexy (8.1%), other hypersomnia conditions (9.5%), delayed sleep phase syndrome (12.2%), behaviorally induced insufficient sleep syndrome (4.1%), other sleep disorders (obstructive sleep apnea, periodic limb movements of sleep; 6.8%), isolated cataplexy (2%), and various diagnoses (29.1%). There were 54.8% of the N+C patients who had an nSOREMP, but only 2.4% of all other patients had an nSOREMP. The specificity of an nSOREMP for detection of N+C was high at 97.3% (95% confidence interval [CI]: 92.2-99.4%), but the sensitivity was moderate at 54.8% (95% CI: 38.7-70.2%). Overall, the positive predictive value of an nSOREMP for the diagnosis of N+C was 88.5% (95% CI: 69.8-97.4%).
conclusionsIn children, the presence of an nocturnal sleep onset rapid eye movement sleep period is highly suggestive of narcolepsy with cataplexy and provides further evidence of rapid eye movement sleep dysregulation in this condition.
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