Observational studySleep2015
Differential sleep, sleepiness, and neurophysiology in the insomnia phenotypes of shift work disorder.
Observational study in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Sleep quality among clinical postgraduate students: a cross-sectional study in Kerala, India.BMC public health · 2025Article
- Shift work sleep disorder in nurses: a concept analysis.BMC nursing · 2025Review
- Exploring predictors of insomnia severity in shift workers using machine learning model.Frontiers in public health · 2025Article
- Network analysis to estimate central insomnia symptoms among daytime workers at-risk for insomnia.Scientific reports · 2023Article
- Personalized sleep-wake patterns aligned with circadian rhythm relieve daytime sleepiness.iScience · 2021Article
- Psychosocial Features of Shift Work Disorder.Brain sciences · 2021Article
- Shift Work Disorder, Insomnia, and Depression among Offshore Oil Rig Workers.Iranian journal of psychiatry · 2021Article
- Convergent and divergent functional connectivityalterations of hippocampal subregions between short-term and chronic insomnia disorder.Brain imaging and behavior · 2021Article
- Fidelity of Information Processing on a Psychomotor Vigilance Task Predicts Changes in Self-Reported Sleepiness Ratings.Nature and science of sleep · 2021Article
- A scoping review of the evidence for the impact of pharmacological and non-pharmacological interventions on shift work related sleep disturbance in an occupational setting.Wellcome open research · 2021Article
- Employees with shift work disorder experience excessive sleepiness also on non-work days: a cross-sectional survey linked to working hours register in Finnish hospitals.Industrial health · 2020Article
- Sleep and alertness in shift work disorder: findings of a field study.International archives of occupational and environmental health · 2019Article
- Association of health literacy and sleep problems with mental health of Chinese students in combined junior and senior high school.PloS one · 2019Article
- The impact of stress on sleep: Pathogenic sleep reactivity as a vulnerability to insomnia and circadian disorders.Journal of sleep research · 2018Review
- Using the Analytic Network Process Method for Prioritizing and Weighing Shift Work Disorders Among the Personnel of Hospitals of Kerman University of Medical Sciences.Journal of circadian rhythms · 2018Article
- Daytime Sleep Disturbance in Night Shift Work and the Role ofJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Enhanced Network Efficiency of Functional Brain Networks in Primary Insomnia Patients.Frontiers in psychiatry · 2018Article
- Review
- Insomnia in shift work disorder relates to occupational and neurophysiological impairment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Article
- Prevalence of insomnia in shift workers: a systematic review.Sleep science (Sao Paulo, Brazil)Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesTo characterize and compare insomnia symptoms within two common phenotypes of Shift Work Disorder.
designObservational laboratory and field study.
settingHospital sleep center.
participants34 permanent night workers. Subjects were classified by Epworth Sleepiness Scale and Insomnia Severity Index into 3 subgroups: asymptomatic controls, alert insomniacs (AI), and sleepy insomniacs (SI). MEASUREMENTS: Sleep parameters were assessed by sleep diary. Circadian phase was evaluated by dim-light salivary melatonin onset (DLMO). Objective sleepiness was measured using the multiple sleep latency test (MSLT). Brain activity was measured using the N1 event-related potential (ERP). A tandem repeat in PER3 was genotyped from saliva DNA.
results(1) AI group showed normal MSLT scores but elevated N1 amplitudes indicating cortical hyperarousal. (2) SI group showed pathologically low MSLT scores but normal N1 amplitudes. (3) AI and SI groups were not significantly different from one another in circadian phase, while controls were significantly phase-delayed relative to both SWD groups. (4) AI showed significantly longer sleep latencies and lower sleep efficiency than controls during both nocturnal and diurnal sleep. SI significantly differed from controls in nocturnal sleep parameters, but differences during diurnal sleep periods were smaller and not statistically significant. (5) Genotype × phenotype χ² analysis showed significant differences in the PER3 VNTR: 9 of 10 shift workers reporting sleepiness in a post hoc genetic substudy were found to carry the long tandem repeat on PER3, while 4 of 14 shift workers without excessive sleepiness carried the long allele.
conclusionsOur results suggest that the sleepy insomnia phenotype is comprehensively explained by circadian misalignment, while the alert insomnia phenotype resembles an insomnia disorder precipitated by shift work.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.