ArticleSleep2015
The heritability of insomnia progression during childhood/adolescence: results from a longitudinal twin study.
Article in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Effectiveness of Cognitive Behavioural Therapy for Insomnia (CBT-I) in Individuals With Neurodevelopmental Conditions: A Systematic Review.Journal of sleep research · 2025Pooled it
- Association Between Disturbed Sleep and Depression in Children and Youths: A Systematic Review and Meta-analysis of Cohort Studies.JAMA network open · 2021Pooled it
- Gender Difference in the Prevalence of Insomnia: A Meta-Analysis of Observational Studies.Frontiers in psychiatry · 2020Pooled it
- Article
- Evaluation of environmental-genetic factors and mental health outcomes for sleep disturbance from late childhood to early adolescence.European child & adolescent psychiatry · 2026Article
- Genetic and environmental influence on resting state networks in young male and female adults: a cartographer mapping study.Human brain mapping · 2023Article
- Child Eveningness as a Predictor of Parental Sleep.Children (Basel, Switzerland) · 2022Article
- Testing Bidirectional, Longitudinal Associations Between Disturbed Sleep and Depressive Symptoms in Children and Adolescents Using Cross-Lagged Models.JAMA network open · 2022Article
- Evaluating the Effects of Diet-Gut Microbiota Interactions on Sleep Traits Using the UK Biobank Cohort.Nutrients · 2022Article
- The Genetics of Sleep Disorders in Children: A Narrative Review.Brain sciences · 2021Review
- Heritability of Sleep and Its Disorders in Childhood and Adolescence.Current sleep medicine reports · 2021Review
- The Different Faces of Insomnia.Frontiers in psychiatry · 2021Article
- Article
- Prevalence and stability of insomnia from preschool to early adolescence: a prospective cohort study in Norway.BMJ paediatrics open · 2020Article
- Sleep: population epidemiology and concordance in Australian children aged 11-12 years and their parents.BMJ open · 2019Article
- Article
- An East Meets West Approach to the Understanding of Emotion Dysregulation in Depression: From Perspective to Scientific Evidence.Frontiers in psychology · 2019Review
- Children's sleep and daytime functioning: Increasing heritability and environmental associations with sibling conflict.Social development (Oxford, England) · 2018Article
- Mean Blood Pressure Difference among Adolescents Based on Dyssomnia Types.Open access Macedonian journal of medical sciences · 2018Article
- Genetic Pathways to Insomnia.Brain sciences · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
STUDY
objectivesTo determine prevalence and heritability of insomnia during middle/late childhood and adolescence; examine longitudinal associations in insomnia over time; and assess the extent to which genetic and environmental factors on insomnia remain stable, or whether new factors come into play, across this developmental period.
designLongitudinal twin study.
settingAcademic medical center. PATIENTS OR
participantsThere were 739 complete monozygotic twin pairs (52%) and 672 complete dizygotic twin pairs (48%) initially enrolled and were followed up at three additional time points (waves). Mode ages at each wave were 8, 10, 14, and 15 y (ages ranged from 8-18 y).
interventionsNone. MEASUREMENTS AND
resultsClinical ratings of insomnia symptoms were assessed using the Child and Adolescent Psychiatric Assessment (CAPA) by trained clinicians, and rated according to Diagnostic and Statistical Manual of Mental Disorders (DSM)-III-R criteria for presence of 'clinically significant insomnia', over four sequential waves. Insomnia symptoms were prevalent but significantly decreased across the four waves (ranging from 16.6% to 31.2%). 'Clinically significant insomnia' was moderately heritable at all waves (h² range = 14% to 38%), and the remaining source of variance was the nonshared environment. Multivariate models indicated that genetic influences at wave 1 contributed to insomnia at all subsequent waves, and that new genetic influences came into play at wave 2, which further contributed to stability of symptoms. Nonshared environmental influences were time-specific.
conclusionInsomnia is prevalent in childhood and adolescence, and is moderately heritable. The progression of insomnia across this developmental time period is influenced by stable as well as new genetic factors that come into play at wave 2 (modal age 10 y). Molecular genetic studies should now identify genes related to insomnia progression during childhood and adolescence.
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